TY - JOUR
T1 - Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation
AU - the Hemodialysis Fistula Maturation Study Group
AU - Kubiak, Rachel W.
AU - Zelnick, Leila R.
AU - Hoofnagle, Andy N.
AU - Alpers, Charles E.
AU - Terry, Christi M.
AU - Shiu, Yan Ting
AU - Cheung, Alfred K.
AU - de Boer, Ian H.
AU - Robinson-Cohen, Cassianne
AU - Allon, Michael
AU - Dember, Laura M.
AU - Feldman, Harold I.
AU - Himmelfarb, Jonathan
AU - Huber, Thomas S.
AU - Roy-Chaudhury, Prabir
AU - Vazquez, Miguel A.
AU - Kusek, John W.
AU - Beck, Gerald J.
AU - Imrey, Peter B.
AU - Kestenbaum, Bryan
AU - Farber, A.
AU - Kaufman, J.
AU - Stern, L.
AU - LeSage, P.
AU - Kivork, C.
AU - Soares, D.
AU - Malikova, M.
AU - Young, C.
AU - Taylor, M.
AU - Woodard, L.
AU - Mangadi, K.
AU - Munda, R.
AU - Lee, T.
AU - Alloway, R.
AU - El-Khatib, M.
AU - Canaan, T.
AU - Pflum, A.
AU - Thieken, L.
AU - Campos-Naciff, B.
AU - Berceli, S.
AU - Jansen, M.
AU - McCaslin, G.
AU - Trahan, Y.
AU - Vongpatanasin, W.
AU - Davidson, I.
AU - Hwang, C.
AU - Lightfoot, T.
AU - Livingston, C.
AU - Valencia, A.
AU - Diener-West, M.
N1 - Funding Information:
The HFM Study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases grants U01DK082179 , U01DK082189 , U01DK082218 , U01DK082222 , U01DK082232 , U01DK082236 , and U01DK082240 . This ancillary study was funded by grant R01DK094891 .
Publisher Copyright:
© 2019 European Society for Vascular Surgery
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Background: The arteriovenous fistula (AVF) is central to haemodialysis treatment, but up to half of surgically created AVF fail to mature. Chronic kidney disease often leads to mineral metabolism disturbances that may interfere with AVF maturation through adverse vascular effects. This study tested associations between mineral metabolism markers and vein histology at AVF creation and unassisted and overall clinical AVF maturation. Methods: Concentrations of fibroblast growth factor 23, parathyroid hormone, calcium, phosphate, and vitamin D metabolites: 1,25(OH)2D, 24,25(OH)2D, 25(OH)D, and bioavailable 25(OH)D were measured in pre-operative serum samples from 562 of 602 participants in the Haemodialysis Fistula Maturation Study, a multicentre, prospective cohort study of patients undergoing surgical creation of an autologous upper extremity AVF. Unassisted and overall AVF maturation were ascertained for 540 and 527 participants, respectively, within nine months of surgery or four weeks of dialysis initiation. Study personnel obtained vein segments adjacent to the portion of the vein used for anastomosis, which were processed, embedded, and stained for measurement of neointimal hyperplasia, calcification, and collagen deposition in the medial wall. Results: Participants in this substudy were 71% male, 43% black, and had a mean age of 55 years. Failure to achieve AVF maturation without assistance occurred in 288 (53%) participants for whom this outcome was determined. In demographic and further adjusted models, mineral metabolism markers were not significantly associated with vein histology characteristics, unassisted AVF maturation failure, or overall maturation failure, other than a biologically unexplained association of higher 24,25(OH)2D with overall failure. This exception aside, associations were non-significant for continuous and categorical analyses and relevant subgroups. Conclusions: Serum concentrations of measured mineral metabolites were not substantially associated with major histological characteristics of veins in patients undergoing AVF creation surgery, or with AVF maturation failure, suggesting that efforts to improve AVF maturation rates should increase attention to other processes such as vein mechanics, anatomy, and cellular metabolism among end stage renal disease patients.
AB - Background: The arteriovenous fistula (AVF) is central to haemodialysis treatment, but up to half of surgically created AVF fail to mature. Chronic kidney disease often leads to mineral metabolism disturbances that may interfere with AVF maturation through adverse vascular effects. This study tested associations between mineral metabolism markers and vein histology at AVF creation and unassisted and overall clinical AVF maturation. Methods: Concentrations of fibroblast growth factor 23, parathyroid hormone, calcium, phosphate, and vitamin D metabolites: 1,25(OH)2D, 24,25(OH)2D, 25(OH)D, and bioavailable 25(OH)D were measured in pre-operative serum samples from 562 of 602 participants in the Haemodialysis Fistula Maturation Study, a multicentre, prospective cohort study of patients undergoing surgical creation of an autologous upper extremity AVF. Unassisted and overall AVF maturation were ascertained for 540 and 527 participants, respectively, within nine months of surgery or four weeks of dialysis initiation. Study personnel obtained vein segments adjacent to the portion of the vein used for anastomosis, which were processed, embedded, and stained for measurement of neointimal hyperplasia, calcification, and collagen deposition in the medial wall. Results: Participants in this substudy were 71% male, 43% black, and had a mean age of 55 years. Failure to achieve AVF maturation without assistance occurred in 288 (53%) participants for whom this outcome was determined. In demographic and further adjusted models, mineral metabolism markers were not significantly associated with vein histology characteristics, unassisted AVF maturation failure, or overall maturation failure, other than a biologically unexplained association of higher 24,25(OH)2D with overall failure. This exception aside, associations were non-significant for continuous and categorical analyses and relevant subgroups. Conclusions: Serum concentrations of measured mineral metabolites were not substantially associated with major histological characteristics of veins in patients undergoing AVF creation surgery, or with AVF maturation failure, suggesting that efforts to improve AVF maturation rates should increase attention to other processes such as vein mechanics, anatomy, and cellular metabolism among end stage renal disease patients.
KW - Arteriovenous fistula
KW - Chronic kidney disease
KW - Haemodialysis
KW - Mineral metabolism
KW - Vein histology
KW - Vitamin D
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U2 - 10.1016/j.ejvs.2019.01.022
DO - 10.1016/j.ejvs.2019.01.022
M3 - Article
C2 - 31000459
AN - SCOPUS:85062949806
SN - 1078-5884
VL - 57
SP - 719
EP - 728
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
IS - 5
ER -