TY - JOUR
T1 - Mineral homeostasis in obesity
T2 - Effects of euglycemic hyperinsulinemia
AU - Kerstetter, Jane
AU - Caballero, Benjamin
AU - O'Brien, Kimberly
AU - Wurtman, Richard
AU - Allen, Lindsay
N1 - Funding Information:
From the School of Allied Health Professions and Nuhitional Sciences Department, University of Connecticut, Storrs, CT: and the Massachusetts Institute of Technology, Clinical Research Center, Cambridge, MA. Supported by National Institutes of Health Grant No. MOI-RR88 to the MIT CRC, and Scientific Contribution No. 13.5% Storrs Agricultural Experiment Station, University of Connecticut. Dr Caballero‘s present address is Center for Human Nutrition, Johns Hopkins University, Baltimore. MD 21205. Address reprint requests to Jane E. Kerstetter, PhD, RD, School of Allied Health Professions, Box V-101, 358 Mansfield Rd, University of Connecticut, Storrs, CT 06269-2101. Copyright 0 1991 by W.B. Saunders Company 0026-0495/91/4007-0009$03.00l0
PY - 1991/7
Y1 - 1991/7
N2 - We explored the effects of insulin on mineral homeostasis in five lean and six moderately obese nondiabetic premenopausal women. Serum and urine minerals were measured before and during the steady-state phase of a euglycemic insulin clamp. Each subject participated in two insulin clamp studies on separate days at insulin infusion rates of 10 and 40 mU/m2/min. Euglycemic hyperinsulinemia was associated with (1) a significant increase in urinary calcium excretion when expressed per minute with no change in total serum calcium; (2) a decrease in urine and serum phosphate; (3) a decrease in serum potassium with no change in urine potassium; and (4) no measurable effects on urine or serum sodium. At any given insulin level, the obese individuals excreted significantly more calcium, phosphate, and potassium per minute than lean controls. While insulin administration had no effect on serum parathyroid hormone (PTH) or vitamin D levels, baseline serum 1,25(OH)2D concentration was significantly higher and serum ultrafilterable calcium was significantly lower in obese subjects than in lean controls.
AB - We explored the effects of insulin on mineral homeostasis in five lean and six moderately obese nondiabetic premenopausal women. Serum and urine minerals were measured before and during the steady-state phase of a euglycemic insulin clamp. Each subject participated in two insulin clamp studies on separate days at insulin infusion rates of 10 and 40 mU/m2/min. Euglycemic hyperinsulinemia was associated with (1) a significant increase in urinary calcium excretion when expressed per minute with no change in total serum calcium; (2) a decrease in urine and serum phosphate; (3) a decrease in serum potassium with no change in urine potassium; and (4) no measurable effects on urine or serum sodium. At any given insulin level, the obese individuals excreted significantly more calcium, phosphate, and potassium per minute than lean controls. While insulin administration had no effect on serum parathyroid hormone (PTH) or vitamin D levels, baseline serum 1,25(OH)2D concentration was significantly higher and serum ultrafilterable calcium was significantly lower in obese subjects than in lean controls.
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U2 - 10.1016/0026-0495(91)90088-E
DO - 10.1016/0026-0495(91)90088-E
M3 - Article
C2 - 1870424
AN - SCOPUS:0025781127
SN - 0026-0495
VL - 40
SP - 707
EP - 713
JO - Metabolism
JF - Metabolism
IS - 7
ER -