Mindfulness and dynamic functional neural connectivity in children and adolescents

Hilary A. Marusak, Farrah Elrahal, Craig A. Peters, Prantik Kundu, Michael V. Lombardo, Vince D. Calhoun, Elimelech K. Goldberg, Cindy Cohen, Jeffrey W. Taub, Christine A. Rabinak

Research output: Research - peer-reviewArticle

Abstract

Background Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings. Methods Using multi-echo multi-band fMRI, we examined dynamic (i.e., time-varying) and conventional static resting-state connectivity between core neurocognitive networks (i.e., salience/emotion, default mode, central executive) in 42 children and adolescents (ages 6–17). Results We found that trait mindfulness in youth relates to dynamic but not static resting-state connectivity. Specifically, more mindful youth transitioned more between brain states over the course of the scan, spent overall less time in a certain connectivity state, and showed a state-specific reduction in connectivity between salience/emotion and central executive networks. The number of state transitions mediated the link between higher mindfulness and lower anxiety, providing new insights into potential neural mechanisms underlying benefits of mindfulness on psychological health in youth. Conclusions Our results provide new evidence that mindfulness in youth relates to functional neural dynamics and interactions between neurocognitive networks, over time.

LanguageEnglish (US)
Pages211-218
Number of pages8
JournalBehavioural Brain Research
Volume336
DOIs
StatePublished - Jan 15 2018

Fingerprint

Mindfulness
Emotions
Cognition
Anxiety
Magnetic Resonance Imaging
Psychology
Health
Brain

Keywords

  • Default mode network
  • Independent components analysis
  • Intrinsic connectivity
  • Meditation
  • Resting-state
  • Salience network

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Marusak, H. A., Elrahal, F., Peters, C. A., Kundu, P., Lombardo, M. V., Calhoun, V. D., ... Rabinak, C. A. (2018). Mindfulness and dynamic functional neural connectivity in children and adolescents. Behavioural Brain Research, 336, 211-218. DOI: 10.1016/j.bbr.2017.09.010

Mindfulness and dynamic functional neural connectivity in children and adolescents. / Marusak, Hilary A.; Elrahal, Farrah; Peters, Craig A.; Kundu, Prantik; Lombardo, Michael V.; Calhoun, Vince D.; Goldberg, Elimelech K.; Cohen, Cindy; Taub, Jeffrey W.; Rabinak, Christine A.

In: Behavioural Brain Research, Vol. 336, 15.01.2018, p. 211-218.

Research output: Research - peer-reviewArticle

Marusak, HA, Elrahal, F, Peters, CA, Kundu, P, Lombardo, MV, Calhoun, VD, Goldberg, EK, Cohen, C, Taub, JW & Rabinak, CA 2018, 'Mindfulness and dynamic functional neural connectivity in children and adolescents' Behavioural Brain Research, vol 336, pp. 211-218. DOI: 10.1016/j.bbr.2017.09.010
Marusak HA, Elrahal F, Peters CA, Kundu P, Lombardo MV, Calhoun VD et al. Mindfulness and dynamic functional neural connectivity in children and adolescents. Behavioural Brain Research. 2018 Jan 15;336:211-218. Available from, DOI: 10.1016/j.bbr.2017.09.010
Marusak, Hilary A. ; Elrahal, Farrah ; Peters, Craig A. ; Kundu, Prantik ; Lombardo, Michael V. ; Calhoun, Vince D. ; Goldberg, Elimelech K. ; Cohen, Cindy ; Taub, Jeffrey W. ; Rabinak, Christine A./ Mindfulness and dynamic functional neural connectivity in children and adolescents. In: Behavioural Brain Research. 2018 ; Vol. 336. pp. 211-218
@article{a765133ecfe143948ace13700c46661d,
title = "Mindfulness and dynamic functional neural connectivity in children and adolescents",
abstract = "Background Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings. Methods Using multi-echo multi-band fMRI, we examined dynamic (i.e., time-varying) and conventional static resting-state connectivity between core neurocognitive networks (i.e., salience/emotion, default mode, central executive) in 42 children and adolescents (ages 6–17). Results We found that trait mindfulness in youth relates to dynamic but not static resting-state connectivity. Specifically, more mindful youth transitioned more between brain states over the course of the scan, spent overall less time in a certain connectivity state, and showed a state-specific reduction in connectivity between salience/emotion and central executive networks. The number of state transitions mediated the link between higher mindfulness and lower anxiety, providing new insights into potential neural mechanisms underlying benefits of mindfulness on psychological health in youth. Conclusions Our results provide new evidence that mindfulness in youth relates to functional neural dynamics and interactions between neurocognitive networks, over time.",
keywords = "Default mode network, Independent components analysis, Intrinsic connectivity, Meditation, Resting-state, Salience network",
author = "Marusak, {Hilary A.} and Farrah Elrahal and Peters, {Craig A.} and Prantik Kundu and Lombardo, {Michael V.} and Calhoun, {Vince D.} and Goldberg, {Elimelech K.} and Cindy Cohen and Taub, {Jeffrey W.} and Rabinak, {Christine A.}",
year = "2018",
month = "1",
doi = "10.1016/j.bbr.2017.09.010",
volume = "336",
pages = "211--218",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

TY - JOUR

T1 - Mindfulness and dynamic functional neural connectivity in children and adolescents

AU - Marusak,Hilary A.

AU - Elrahal,Farrah

AU - Peters,Craig A.

AU - Kundu,Prantik

AU - Lombardo,Michael V.

AU - Calhoun,Vince D.

AU - Goldberg,Elimelech K.

AU - Cohen,Cindy

AU - Taub,Jeffrey W.

AU - Rabinak,Christine A.

PY - 2018/1/15

Y1 - 2018/1/15

N2 - Background Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings. Methods Using multi-echo multi-band fMRI, we examined dynamic (i.e., time-varying) and conventional static resting-state connectivity between core neurocognitive networks (i.e., salience/emotion, default mode, central executive) in 42 children and adolescents (ages 6–17). Results We found that trait mindfulness in youth relates to dynamic but not static resting-state connectivity. Specifically, more mindful youth transitioned more between brain states over the course of the scan, spent overall less time in a certain connectivity state, and showed a state-specific reduction in connectivity between salience/emotion and central executive networks. The number of state transitions mediated the link between higher mindfulness and lower anxiety, providing new insights into potential neural mechanisms underlying benefits of mindfulness on psychological health in youth. Conclusions Our results provide new evidence that mindfulness in youth relates to functional neural dynamics and interactions between neurocognitive networks, over time.

AB - Background Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings. Methods Using multi-echo multi-band fMRI, we examined dynamic (i.e., time-varying) and conventional static resting-state connectivity between core neurocognitive networks (i.e., salience/emotion, default mode, central executive) in 42 children and adolescents (ages 6–17). Results We found that trait mindfulness in youth relates to dynamic but not static resting-state connectivity. Specifically, more mindful youth transitioned more between brain states over the course of the scan, spent overall less time in a certain connectivity state, and showed a state-specific reduction in connectivity between salience/emotion and central executive networks. The number of state transitions mediated the link between higher mindfulness and lower anxiety, providing new insights into potential neural mechanisms underlying benefits of mindfulness on psychological health in youth. Conclusions Our results provide new evidence that mindfulness in youth relates to functional neural dynamics and interactions between neurocognitive networks, over time.

KW - Default mode network

KW - Independent components analysis

KW - Intrinsic connectivity

KW - Meditation

KW - Resting-state

KW - Salience network

UR - http://www.scopus.com/inward/record.url?scp=85028974319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028974319&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2017.09.010

DO - 10.1016/j.bbr.2017.09.010

M3 - Article

VL - 336

SP - 211

EP - 218

JO - Behavioural Brain Research

T2 - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -