TY - JOUR
T1 - Mindfulness and dynamic functional neural connectivity in children and adolescents
AU - Marusak, Hilary A.
AU - Elrahal, Farrah
AU - Peters, Craig A.
AU - Kundu, Prantik
AU - Lombardo, Michael V.
AU - Calhoun, Vince D.
AU - Goldberg, Elimelech K.
AU - Cohen, Cindy
AU - Taub, Jeffrey W.
AU - Rabinak, Christine A.
N1 - Funding Information:
Research reported in this publication was supported, in part, by the Department of Pharmacy Practice , the Department of Pediatrics , and the Merrill Palmer Skillman Institute of Wayne State University (WSU) , NIH National Institute of Biomedical Imaging and Bioengineering awards P20GM103472 , R01EB006841 (VDC), and R01EB020407 (VDC), National Science Foundation grant 1539067 (VDC), and American Cancer Society and Karmanos Cancer Institute Institutional Research Grant 14-238-04-IRG (CAR). Dr. Marusak is supported by American Cancer Society award 129368-PF-16-057-01-PCSM . Dr. Rabinak is supported by NIH National Institute of Mental Health grant K01MH101123 and R61MH111935 .
Publisher Copyright:
© 2017 Elsevier B.V.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/1/15
Y1 - 2018/1/15
N2 - Background Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings. Methods Using multi-echo multi-band fMRI, we examined dynamic (i.e., time-varying) and conventional static resting-state connectivity between core neurocognitive networks (i.e., salience/emotion, default mode, central executive) in 42 children and adolescents (ages 6–17). Results We found that trait mindfulness in youth relates to dynamic but not static resting-state connectivity. Specifically, more mindful youth transitioned more between brain states over the course of the scan, spent overall less time in a certain connectivity state, and showed a state-specific reduction in connectivity between salience/emotion and central executive networks. The number of state transitions mediated the link between higher mindfulness and lower anxiety, providing new insights into potential neural mechanisms underlying benefits of mindfulness on psychological health in youth. Conclusions Our results provide new evidence that mindfulness in youth relates to functional neural dynamics and interactions between neurocognitive networks, over time.
AB - Background Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings. Methods Using multi-echo multi-band fMRI, we examined dynamic (i.e., time-varying) and conventional static resting-state connectivity between core neurocognitive networks (i.e., salience/emotion, default mode, central executive) in 42 children and adolescents (ages 6–17). Results We found that trait mindfulness in youth relates to dynamic but not static resting-state connectivity. Specifically, more mindful youth transitioned more between brain states over the course of the scan, spent overall less time in a certain connectivity state, and showed a state-specific reduction in connectivity between salience/emotion and central executive networks. The number of state transitions mediated the link between higher mindfulness and lower anxiety, providing new insights into potential neural mechanisms underlying benefits of mindfulness on psychological health in youth. Conclusions Our results provide new evidence that mindfulness in youth relates to functional neural dynamics and interactions between neurocognitive networks, over time.
KW - Default mode network
KW - Independent components analysis
KW - Intrinsic connectivity
KW - Meditation
KW - Resting-state
KW - Salience network
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U2 - 10.1016/j.bbr.2017.09.010
DO - 10.1016/j.bbr.2017.09.010
M3 - Article
C2 - 28887198
AN - SCOPUS:85028974319
VL - 336
SP - 211
EP - 218
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -