Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway

Ki Jun Yoon, Hye Ryeon Lee, Yong Sang Jo, Kyongman An, Sang Yong Jung, Min Woo Jeong, Seok Kyu Kwon, Nam Shik Kim, Hyun Woo Jeong, Seo Hee Ahn, Kyong Tai Kim, Kyungmin Lee, Eunjoon Kim, Joung Hun Kim, June Seek Choi, Bong Kiun Kaang, Young Yun Kong

Research output: Contribution to journalArticle

Abstract

Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.

Original languageEnglish (US)
Article number40
JournalMolecular Brain
Volume5
Issue number1
DOIs
StatePublished - Oct 31 2012

Keywords

  • Hippocampus
  • Memory
  • Mind bomb-1
  • Notch
  • Synaptic plasticity

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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    Yoon, K. J., Lee, H. R., Jo, Y. S., An, K., Jung, S. Y., Jeong, M. W., Kwon, S. K., Kim, N. S., Jeong, H. W., Ahn, S. H., Kim, K. T., Lee, K., Kim, E., Kim, J. H., Choi, J. S., Kaang, B. K., & Kong, Y. Y. (2012). Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Molecular Brain, 5(1), [40]. https://doi.org/10.1186/1756-6606-5-40