Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway

Ki Jun Yoon; Hye Ryeon Lee; Yong Sang Jo; Kyongman An; Sang Yong Jung; Min Woo Jeong; Seok Kyu Kwon; Nam Shik Kim; Hyun Woo Jeong; Seo Hee Ahn; Kyong Tai Kim; Kyungmin Lee; Eunjoon Kim; Joung Hun Kim; June Seek Choi; Bong Kiun Kaang; Young Yun Kong

doi:10.1186/1756-6606-5-40

Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway

Ki Jun Yoon, Hye Ryeon Lee, Yong Sang Jo, Kyongman An, Sang Yong Jung, Min Woo Jeong, Seok Kyu Kwon, Nam Shik Kim, Hyun Woo Jeong, Seo Hee Ahn, Kyong Tai Kim, Kyungmin Lee, Eunjoon Kim, Joung Hun Kim, June Seek Choi, Bong Kiun Kaang, Young Yun Kong

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.

Original language	English (US)
Article number	40
Journal	Molecular Brain
Volume	5
Issue number	1
DOIs	https://doi.org/10.1186/1756-6606-5-40
State	Published - 2012
Externally published	Yes

Keywords

Hippocampus
Memory
Mind bomb-1
Notch
Synaptic plasticity

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1186/1756-6606-5-40

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Yoon, K. J., Lee, H. R., Jo, Y. S., An, K., Jung, S. Y., Jeong, M. W., Kwon, S. K., Kim, N. S., Jeong, H. W., Ahn, S. H., Kim, K. T., Lee, K., Kim, E., Kim, J. H., Choi, J. S., Kaang, B. K., & Kong, Y. Y. (2012). Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Molecular Brain, 5(1), Article 40. https://doi.org/10.1186/1756-6606-5-40

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title = "Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway",

abstract = "Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.",

keywords = "Hippocampus, Memory, Mind bomb-1, Notch, Synaptic plasticity",

author = "Yoon, {Ki Jun} and Lee, {Hye Ryeon} and Jo, {Yong Sang} and Kyongman An and Jung, {Sang Yong} and Jeong, {Min Woo} and Kwon, {Seok Kyu} and Kim, {Nam Shik} and Jeong, {Hyun Woo} and Ahn, {Seo Hee} and Kim, {Kyong Tai} and Kyungmin Lee and Eunjoon Kim and Kim, {Joung Hun} and Choi, {June Seek} and Kaang, {Bong Kiun} and Kong, {Young Yun}",

note = "Funding Information: We thank the members of Prof. Kong{\textquoteright}s laboratory for discussions, Juhyun Kim for careful reading of the manuscript, and Dr. Douglas Melton for kind material transfer. This research was supported by grants from the Brain Research Center of the 21st Century Frontier Research Program and funded by the Ministry of Science and Technology, the Republic of Korea (2009-K001260) and the Basic Science Research Program through the National Research Foundation of Korea (2012-0000121). B.-K.K was supported by National Creative Research Initiative Program and National Honor Scientist Program, Korea.",

year = "2012",

doi = "10.1186/1756-6606-5-40",

language = "English (US)",

volume = "5",

journal = "Molecular Brain",

issn = "1756-6606",

publisher = "BioMed Central",

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TY - JOUR

T1 - Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway

AU - Yoon, Ki Jun

AU - Lee, Hye Ryeon

AU - Jo, Yong Sang

AU - An, Kyongman

AU - Jung, Sang Yong

AU - Jeong, Min Woo

AU - Kwon, Seok Kyu

AU - Kim, Nam Shik

AU - Jeong, Hyun Woo

AU - Ahn, Seo Hee

AU - Kim, Kyong Tai

AU - Lee, Kyungmin

AU - Kim, Eunjoon

AU - Kim, Joung Hun

AU - Choi, June Seek

AU - Kaang, Bong Kiun

AU - Kong, Young Yun

N1 - Funding Information: We thank the members of Prof. Kong’s laboratory for discussions, Juhyun Kim for careful reading of the manuscript, and Dr. Douglas Melton for kind material transfer. This research was supported by grants from the Brain Research Center of the 21st Century Frontier Research Program and funded by the Ministry of Science and Technology, the Republic of Korea (2009-K001260) and the Basic Science Research Program through the National Research Foundation of Korea (2012-0000121). B.-K.K was supported by National Creative Research Initiative Program and National Honor Scientist Program, Korea.

PY - 2012

Y1 - 2012

N2 - Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.

AB - Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.

KW - Hippocampus

KW - Memory

KW - Mind bomb-1

KW - Notch

KW - Synaptic plasticity

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SN - 1756-6606

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JO - Molecular Brain

JF - Molecular Brain

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M1 - 40

ER -

Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway

Abstract

Keywords

ASJC Scopus subject areas

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