Mimotopes of cytolytic T lymphocytes in cancer immunotherapy

Lieping Chen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Rapid identification of the cytolytic T lymphocyte (CTL) epitopes that are presented by cancer cells will provide the basis for manipulation of tumor immunity but remains a major challenge in the field. By screening randomly synthesized peptide libraries, mimotopes for tumor-reactive CTLs can be readily constructed and they may be functionally equal to or potentially more potent than natural peptides in stimulating CTL responses; therefore, the peptide library approach provides great promise for design of cancer vaccines and adoptive tumor immunotherapy.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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