Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

Kelley A. Brix; David L. Brody; Jamie B. Grimes; Avraham Yitzhak; Denes Agoston; Matt Aldag; Regina Armstrong; Peethambaran Arun; Michel Audette; Debra Babcock; Carey Balaban; Rohan Banton; Patrick Bellgowan; David Borkholder; Steven Broglio; Elizabeth Brokaw; Robert Cantu; Walter Carr; Sandi Chapman; Joan Cmarik; Brian Colder; Jeff Colombe; David Cook; Tara Cozzarelli; Uade Olaghere Da Silva; Nitin Daphalapurkar; Bernard Dardzinski; Tom DeGraba; James DeMar; Douglas DeWitt; Dara Dickstein; Josh Duckworth; Gregory Elder; Reza Fazel-Rezai; Michael Fine; Gary Fiskum; Adam Fournier; Shaleish Ganpule; Jessica Gill; John F. Glenn; Colin Greene; Nigel Greig; Chad Haering; Jason Harrington; Amy Hein; Kathy Helmick; Ramona Hicks; Sidney Hinds; Stuart Hoffman; Iren Horkayne-Szakaly; Diego Iacono; Erick Ishii; Robert V. Jones; Ghodrat Karami; Daniel Krawczyk; Robert Labutta; Robert Latta; Theresa Lattimore; Michael Leggieri; Fabio Leonessa; Alexander Lin; Geoffrey Ling; Matt Long; Kun Ping Lu; Stephanie Maxfield Panker; Joseph McCabe; Andrew Merkle; Philip Montenigro; Gary P. Mueller; Laurel Ng; Savita Nigam; John O'Donnell; David Okonkwo; Ingrid Pauli; Daniel Perl; Elaine Peskind; Bryan Pfister; Mat Philippens; Thuvan Piehler; Julie Proctor; Andrzej Przekwas; Felicia Qashu; Murray Raskind; Alexander Razumovsky; Jaques Reifman; Patricio Reyes; Paul Rigby; Marten Risling; Meghan Robinson; Tyler Rooks; Charles Rosen; Gail Rosseau; Wendy Sammons-Jackson; Anthony Santago; Richard Shoge; Chandler Sours; James Stone; Mike Templin; Victoria Tepe; Peter Thielen; Mike Thomas; Thomas Timmes; Frank Tortella; Laura Tucker; David Tweedie; Dale Vander Hamm; B. Christie Vu; Ying Wang; Therese West; Elisabeth Wilde; Adam Willis; John Wu; Laila Zai; Nikki Zander; James Zheng; Mariusz Ziejewski

doi:10.1089/neu.2017.5222

Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

Kelley A. Brix, David L. Brody, Jamie B. Grimes, Avraham Yitzhak, Denes Agoston, Matt Aldag, Regina Armstrong, Peethambaran Arun, Michel Audette, Debra Babcock, Carey Balaban, Rohan Banton, Patrick Bellgowan, David Borkholder, Steven Broglio, Elizabeth Brokaw, Robert Cantu, Walter Carr, Sandi Chapman, Joan CmarikBrian Colder, Jeff Colombe, David Cook, Tara Cozzarelli, Uade Olaghere Da Silva, Nitin Daphalapurkar, Bernard Dardzinski, Tom DeGraba, James DeMar, Douglas DeWitt, Dara Dickstein, Josh Duckworth, Gregory Elder, Reza Fazel-Rezai, Michael Fine, Gary Fiskum, Adam Fournier, Shaleish Ganpule, Jessica Gill, John F. Glenn, Colin Greene, Nigel Greig, Chad Haering, Jason Harrington, Amy Hein, Kathy Helmick, Ramona Hicks, Sidney Hinds, Stuart Hoffman, Iren Horkayne-Szakaly, Diego Iacono, Erick Ishii, Robert V. Jones, Ghodrat Karami, Daniel Krawczyk, Robert Labutta, Robert Latta, Theresa Lattimore, Michael Leggieri, Fabio Leonessa, Alexander Lin, Geoffrey Ling, Matt Long, Kun Ping Lu, Stephanie Maxfield Panker, Joseph McCabe, Andrew Merkle, Philip Montenigro, Gary P. Mueller, Laurel Ng, Savita Nigam, John O'Donnell, David Okonkwo, Ingrid Pauli, Daniel Perl, Elaine Peskind, Bryan Pfister, Mat Philippens, Thuvan Piehler, Julie Proctor, Andrzej Przekwas, Felicia Qashu, Murray Raskind, Alexander Razumovsky, Jaques Reifman, Patricio Reyes, Paul Rigby, Marten Risling, Meghan Robinson, Tyler Rooks, Charles Rosen, Gail Rosseau, Wendy Sammons-Jackson, Anthony Santago, Richard Shoge, Chandler Sours, James Stone, Mike Templin, Victoria Tepe, Peter Thielen, Mike Thomas, Thomas Timmes, Frank Tortella, Laura Tucker, David Tweedie, Dale Vander Hamm, B. Christie Vu, Ying Wang, Therese West, Elisabeth Wilde, Adam Willis, John Wu, Laila Zai, Nikki Zander, James Zheng, Mariusz Ziejewski

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury Research Program Coordinating Office organized the 2015 International State-of-The-Science Meeting, which brought together subject matter experts from the DoD, other federal agencies, academia, industry, foreign allies, and the sports community. Over the course of the meeting, this community of experts reached a consensus regarding the current body of knowledge and the future of the field. The overarching finding was that there is insufficient existing scientific evidence to link blast-related TBI with CTE. The meeting's Expert Panel also agreed on 13 additional findings describing research and knowledge gaps, clinical gaps, and research opportunities that, if addressed with focused effort, would further the understanding of the relationship between blast-related TBI and CTE. To this end, the Expert Panel also developed six recommendations for advancing research, each with short-and long-Term goals. Among the six recommendations, the Expert Panel identified the first four as highest priority for addressing pressing research needs. These four high-priority recommendations include, in order of priority: (1) more collection and study of clinical neuropathology samples, (2) standardization of clinical diagnostic criteria, (3) development of clinically appropriate and standardized animal models, and (4) development of noninvasive serial assessment strategies (i.e., imaging or biospecimen biomarkers).

Original language	English (US)
Pages (from-to)	S18-S25
Journal	Journal of neurotrauma
Volume	34
Issue number	S1
DOIs	https://doi.org/10.1089/neu.2017.5222
State	Published - Sep 2017
Externally published	Yes

Keywords

blast-related injury
chronic traumatic encephalopathy (CTE)
traumatic brain injury (TBI)

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1089/neu.2017.5222

Cite this

Brix, K. A., Brody, D. L., Grimes, J. B., Yitzhak, A., Agoston, D., Aldag, M., Armstrong, R., Arun, P., Audette, M., Babcock, D., Balaban, C., Banton, R., Bellgowan, P., Borkholder, D., Broglio, S., Brokaw, E., Cantu, R., Carr, W., Chapman, S., ... Ziejewski, M. (2017). Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations. Journal of neurotrauma, 34(S1), S18-S25. https://doi.org/10.1089/neu.2017.5222

Brix, KA, Brody, DL, Grimes, JB, Yitzhak, A, Agoston, D, Aldag, M, Armstrong, R, Arun, P, Audette, M, Babcock, D, Balaban, C, Banton, R, Bellgowan, P, Borkholder, D, Broglio, S, Brokaw, E, Cantu, R, Carr, W, Chapman, S, Cmarik, J, Colder, B, Colombe, J, Cook, D, Cozzarelli, T, Da Silva, UO, Daphalapurkar, N, Dardzinski, B, DeGraba, T, DeMar, J, DeWitt, D, Dickstein, D, Duckworth, J, Elder, G, Fazel-Rezai, R, Fine, M, Fiskum, G, Fournier, A, Ganpule, S, Gill, J, Glenn, JF, Greene, C, Greig, N, Haering, C, Harrington, J, Hein, A, Helmick, K, Hicks, R, Hinds, S, Hoffman, S, Horkayne-Szakaly, I, Iacono, D, Ishii, E, Jones, RV, Karami, G, Krawczyk, D, Labutta, R, Latta, R, Lattimore, T, Leggieri, M, Leonessa, F, Lin, A, Ling, G, Long, M, Lu, KP, Panker, SM, McCabe, J, Merkle, A, Montenigro, P, Mueller, GP, Ng, L, Nigam, S, O'Donnell, J, Okonkwo, D, Pauli, I, Perl, D, Peskind, E, Pfister, B, Philippens, M, Piehler, T, Proctor, J, Przekwas, A, Qashu, F, Raskind, M, Razumovsky, A, Reifman, J, Reyes, P, Rigby, P, Risling, M, Robinson, M, Rooks, T, Rosen, C, Rosseau, G, Sammons-Jackson, W, Santago, A, Shoge, R, Sours, C, Stone, J, Templin, M, Tepe, V, Thielen, P, Thomas, M, Timmes, T, Tortella, F, Tucker, L, Tweedie, D, Hamm, DV, Christie Vu, B, Wang, Y, West, T, Wilde, E, Willis, A, Wu, J, Zai, L, Zander, N, Zheng, J & Ziejewski, M 2017, 'Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations', Journal of neurotrauma, vol. 34, no. S1, pp. S18-S25. https://doi.org/10.1089/neu.2017.5222

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title = "Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations",

abstract = "The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury Research Program Coordinating Office organized the 2015 International State-of-The-Science Meeting, which brought together subject matter experts from the DoD, other federal agencies, academia, industry, foreign allies, and the sports community. Over the course of the meeting, this community of experts reached a consensus regarding the current body of knowledge and the future of the field. The overarching finding was that there is insufficient existing scientific evidence to link blast-related TBI with CTE. The meeting's Expert Panel also agreed on 13 additional findings describing research and knowledge gaps, clinical gaps, and research opportunities that, if addressed with focused effort, would further the understanding of the relationship between blast-related TBI and CTE. To this end, the Expert Panel also developed six recommendations for advancing research, each with short-and long-Term goals. Among the six recommendations, the Expert Panel identified the first four as highest priority for addressing pressing research needs. These four high-priority recommendations include, in order of priority: (1) more collection and study of clinical neuropathology samples, (2) standardization of clinical diagnostic criteria, (3) development of clinically appropriate and standardized animal models, and (4) development of noninvasive serial assessment strategies (i.e., imaging or biospecimen biomarkers).",

keywords = "blast-related injury, chronic traumatic encephalopathy (CTE), traumatic brain injury (TBI)",

author = "Brix, {Kelley A.} and Brody, {David L.} and Grimes, {Jamie B.} and Avraham Yitzhak and Denes Agoston and Matt Aldag and Regina Armstrong and Peethambaran Arun and Michel Audette and Debra Babcock and Carey Balaban and Rohan Banton and Patrick Bellgowan and David Borkholder and Steven Broglio and Elizabeth Brokaw and Robert Cantu and Walter Carr and Sandi Chapman and Joan Cmarik and Brian Colder and Jeff Colombe and David Cook and Tara Cozzarelli and {Da Silva}, {Uade Olaghere} and Nitin Daphalapurkar and Bernard Dardzinski and Tom DeGraba and James DeMar and Douglas DeWitt and Dara Dickstein and Josh Duckworth and Gregory Elder and Reza Fazel-Rezai and Michael Fine and Gary Fiskum and Adam Fournier and Shaleish Ganpule and Jessica Gill and Glenn, {John F.} and Colin Greene and Nigel Greig and Chad Haering and Jason Harrington and Amy Hein and Kathy Helmick and Ramona Hicks and Sidney Hinds and Stuart Hoffman and Iren Horkayne-Szakaly and Diego Iacono and Erick Ishii and Jones, {Robert V.} and Ghodrat Karami and Daniel Krawczyk and Robert Labutta and Robert Latta and Theresa Lattimore and Michael Leggieri and Fabio Leonessa and Alexander Lin and Geoffrey Ling and Matt Long and Lu, {Kun Ping} and Panker, {Stephanie Maxfield} and Joseph McCabe and Andrew Merkle and Philip Montenigro and Mueller, {Gary P.} and Laurel Ng and Savita Nigam and John O'Donnell and David Okonkwo and Ingrid Pauli and Daniel Perl and Elaine Peskind and Bryan Pfister and Mat Philippens and Thuvan Piehler and Julie Proctor and Andrzej Przekwas and Felicia Qashu and Murray Raskind and Alexander Razumovsky and Jaques Reifman and Patricio Reyes and Paul Rigby and Marten Risling and Meghan Robinson and Tyler Rooks and Charles Rosen and Gail Rosseau and Wendy Sammons-Jackson and Anthony Santago and Richard Shoge and Chandler Sours and James Stone and Mike Templin and Victoria Tepe and Peter Thielen and Mike Thomas and Thomas Timmes and Frank Tortella and Laura Tucker and David Tweedie and Hamm, {Dale Vander} and {Christie Vu}, B. and Ying Wang and Therese West and Elisabeth Wilde and Adam Willis and John Wu and Laila Zai and Nikki Zander and James Zheng and Mariusz Ziejewski",

year = "2017",

month = sep,

doi = "10.1089/neu.2017.5222",

language = "English (US)",

volume = "34",

pages = "S18--S25",

journal = "Journal of neurotrauma",

issn = "0897-7151",

publisher = "Mary Ann Liebert Inc.",

number = "S1",

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TY - JOUR

T1 - Military Blast Exposure and Chronic Neurodegeneration

T2 - Summary of Working Groups and Expert Panel Findings and Recommendations

AU - Brix, Kelley A.

AU - Brody, David L.

AU - Grimes, Jamie B.

AU - Yitzhak, Avraham

AU - Agoston, Denes

AU - Aldag, Matt

AU - Armstrong, Regina

AU - Arun, Peethambaran

AU - Audette, Michel

AU - Babcock, Debra

AU - Balaban, Carey

AU - Banton, Rohan

AU - Bellgowan, Patrick

AU - Borkholder, David

AU - Broglio, Steven

AU - Brokaw, Elizabeth

AU - Cantu, Robert

AU - Carr, Walter

AU - Chapman, Sandi

AU - Cmarik, Joan

AU - Colder, Brian

AU - Colombe, Jeff

AU - Cook, David

AU - Cozzarelli, Tara

AU - Da Silva, Uade Olaghere

AU - Daphalapurkar, Nitin

AU - Dardzinski, Bernard

AU - DeGraba, Tom

AU - DeMar, James

AU - DeWitt, Douglas

AU - Dickstein, Dara

AU - Duckworth, Josh

AU - Elder, Gregory

AU - Fazel-Rezai, Reza

AU - Fine, Michael

AU - Fiskum, Gary

AU - Fournier, Adam

AU - Ganpule, Shaleish

AU - Gill, Jessica

AU - Glenn, John F.

AU - Greene, Colin

AU - Greig, Nigel

AU - Haering, Chad

AU - Harrington, Jason

AU - Hein, Amy

AU - Helmick, Kathy

AU - Hicks, Ramona

AU - Hinds, Sidney

AU - Hoffman, Stuart

AU - Horkayne-Szakaly, Iren

AU - Iacono, Diego

AU - Ishii, Erick

AU - Jones, Robert V.

AU - Karami, Ghodrat

AU - Krawczyk, Daniel

AU - Labutta, Robert

AU - Latta, Robert

AU - Lattimore, Theresa

AU - Leggieri, Michael

AU - Leonessa, Fabio

AU - Lin, Alexander

AU - Ling, Geoffrey

AU - Long, Matt

AU - Lu, Kun Ping

AU - Panker, Stephanie Maxfield

AU - McCabe, Joseph

AU - Merkle, Andrew

AU - Montenigro, Philip

AU - Mueller, Gary P.

AU - Ng, Laurel

AU - Nigam, Savita

AU - O'Donnell, John

AU - Okonkwo, David

AU - Pauli, Ingrid

AU - Perl, Daniel

AU - Peskind, Elaine

AU - Pfister, Bryan

AU - Philippens, Mat

AU - Piehler, Thuvan

AU - Proctor, Julie

AU - Przekwas, Andrzej

AU - Qashu, Felicia

AU - Raskind, Murray

AU - Razumovsky, Alexander

AU - Reifman, Jaques

AU - Reyes, Patricio

AU - Rigby, Paul

AU - Risling, Marten

AU - Robinson, Meghan

AU - Rooks, Tyler

AU - Rosen, Charles

AU - Rosseau, Gail

AU - Sammons-Jackson, Wendy

AU - Santago, Anthony

AU - Shoge, Richard

AU - Sours, Chandler

AU - Stone, James

AU - Templin, Mike

AU - Tepe, Victoria

AU - Thielen, Peter

AU - Thomas, Mike

AU - Timmes, Thomas

AU - Tortella, Frank

AU - Tucker, Laura

AU - Tweedie, David

AU - Hamm, Dale Vander

AU - Christie Vu, B.

AU - Wang, Ying

AU - West, Therese

AU - Wilde, Elisabeth

AU - Willis, Adam

AU - Wu, John

AU - Zai, Laila

AU - Zander, Nikki

AU - Zheng, James

AU - Ziejewski, Mariusz

PY - 2017/9

Y1 - 2017/9

N2 - The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury Research Program Coordinating Office organized the 2015 International State-of-The-Science Meeting, which brought together subject matter experts from the DoD, other federal agencies, academia, industry, foreign allies, and the sports community. Over the course of the meeting, this community of experts reached a consensus regarding the current body of knowledge and the future of the field. The overarching finding was that there is insufficient existing scientific evidence to link blast-related TBI with CTE. The meeting's Expert Panel also agreed on 13 additional findings describing research and knowledge gaps, clinical gaps, and research opportunities that, if addressed with focused effort, would further the understanding of the relationship between blast-related TBI and CTE. To this end, the Expert Panel also developed six recommendations for advancing research, each with short-and long-Term goals. Among the six recommendations, the Expert Panel identified the first four as highest priority for addressing pressing research needs. These four high-priority recommendations include, in order of priority: (1) more collection and study of clinical neuropathology samples, (2) standardization of clinical diagnostic criteria, (3) development of clinically appropriate and standardized animal models, and (4) development of noninvasive serial assessment strategies (i.e., imaging or biospecimen biomarkers).

AB - The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury Research Program Coordinating Office organized the 2015 International State-of-The-Science Meeting, which brought together subject matter experts from the DoD, other federal agencies, academia, industry, foreign allies, and the sports community. Over the course of the meeting, this community of experts reached a consensus regarding the current body of knowledge and the future of the field. The overarching finding was that there is insufficient existing scientific evidence to link blast-related TBI with CTE. The meeting's Expert Panel also agreed on 13 additional findings describing research and knowledge gaps, clinical gaps, and research opportunities that, if addressed with focused effort, would further the understanding of the relationship between blast-related TBI and CTE. To this end, the Expert Panel also developed six recommendations for advancing research, each with short-and long-Term goals. Among the six recommendations, the Expert Panel identified the first four as highest priority for addressing pressing research needs. These four high-priority recommendations include, in order of priority: (1) more collection and study of clinical neuropathology samples, (2) standardization of clinical diagnostic criteria, (3) development of clinically appropriate and standardized animal models, and (4) development of noninvasive serial assessment strategies (i.e., imaging or biospecimen biomarkers).

KW - blast-related injury

KW - chronic traumatic encephalopathy (CTE)

KW - traumatic brain injury (TBI)

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ER -

Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

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