Mild thyroid hormone excess is associated with a decreased physical function in elderly men

Graziano Ceresini, Gian Paolo Ceda, Fulvio Lauretani, Marcello Maggio, Stefania Bandinelli, Jack M. Guralnik, Anne R. Cappola, Elisa Usberti, Simonetta Morganti, Giorgio Valenti, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review


Introduction: In the adult, subclinical hyperthyroidism (Shyper) may alter skeletal muscle mass and strength. However, whether these effects are present in elderly subjects is not known. We explored the relationship between mild hyperthyroidism and physical function in a population-based sample of older persons. Methods: In a cross-sectional analysis, calf muscle cross-sectional area (CMA), handgrip strength, nerve conduction velocity (NCV), and Short Physical Performance Battery (SPPB) scores were compared between 364 euthyroid (Eut) and 28 Shyper men as well as between 502 Eut and 39 Shyper women. In a longitudinal analysis, we evaluated the relationship between baseline plasma TSH, FT3 and FT4 and the 3-year change in SPPB score in 304 men and 409 women who were euthyroid at enrolment. Results: At the cross-sectional analysis, Shyper men, but not women, had a significantly (p=0.02) lower SPPB score than Eut controls, although with comparable CMA, grip strength and NCV, and were more likely to have poor physical performance (odds ratio=2.97, p

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalAging Male
Issue number4
StatePublished - Dec 2011
Externally publishedYes


  • elderly male
  • physical function
  • Subclinical hyperthyroidism

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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