TY - JOUR
T1 - Mild thyroid hormone excess is associated with a decreased physical function in elderly men
AU - Ceresini, Graziano
AU - Ceda, Gian Paolo
AU - Lauretani, Fulvio
AU - Maggio, Marcello
AU - Bandinelli, Stefania
AU - Guralnik, Jack M.
AU - Cappola, Anne R.
AU - Usberti, Elisa
AU - Morganti, Simonetta
AU - Valenti, Giorgio
AU - Ferrucci, Luigi
PY - 2011/12
Y1 - 2011/12
N2 - Introduction: In the adult, subclinical hyperthyroidism (Shyper) may alter skeletal muscle mass and strength. However, whether these effects are present in elderly subjects is not known. We explored the relationship between mild hyperthyroidism and physical function in a population-based sample of older persons. Methods: In a cross-sectional analysis, calf muscle cross-sectional area (CMA), handgrip strength, nerve conduction velocity (NCV), and Short Physical Performance Battery (SPPB) scores were compared between 364 euthyroid (Eut) and 28 Shyper men as well as between 502 Eut and 39 Shyper women. In a longitudinal analysis, we evaluated the relationship between baseline plasma TSH, FT3 and FT4 and the 3-year change in SPPB score in 304 men and 409 women who were euthyroid at enrolment. Results: At the cross-sectional analysis, Shyper men, but not women, had a significantly (p=0.02) lower SPPB score than Eut controls, although with comparable CMA, grip strength and NCV, and were more likely to have poor physical performance (odds ratio=2.97, p
AB - Introduction: In the adult, subclinical hyperthyroidism (Shyper) may alter skeletal muscle mass and strength. However, whether these effects are present in elderly subjects is not known. We explored the relationship between mild hyperthyroidism and physical function in a population-based sample of older persons. Methods: In a cross-sectional analysis, calf muscle cross-sectional area (CMA), handgrip strength, nerve conduction velocity (NCV), and Short Physical Performance Battery (SPPB) scores were compared between 364 euthyroid (Eut) and 28 Shyper men as well as between 502 Eut and 39 Shyper women. In a longitudinal analysis, we evaluated the relationship between baseline plasma TSH, FT3 and FT4 and the 3-year change in SPPB score in 304 men and 409 women who were euthyroid at enrolment. Results: At the cross-sectional analysis, Shyper men, but not women, had a significantly (p=0.02) lower SPPB score than Eut controls, although with comparable CMA, grip strength and NCV, and were more likely to have poor physical performance (odds ratio=2.97, p
KW - elderly male
KW - physical function
KW - Subclinical hyperthyroidism
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U2 - 10.3109/13685538.2011.606514
DO - 10.3109/13685538.2011.606514
M3 - Article
C2 - 21875391
AN - SCOPUS:80955131492
VL - 14
SP - 213
EP - 219
JO - Aging Male
JF - Aging Male
SN - 1368-5538
IS - 4
ER -