Migraine and white matter hyperintensities

The ARIC MRI study

Ali G. Hamedani, Kathryn M. Rose, B. Lee Peterlin, Thomas H. Mosley, Laura H. Coker, Clifford R. Jack, David S. Knopman, Alvaro Alonso, Rebecca F Gottesman

Research output: Contribution to journalArticle

Abstract

Objective: Migraine is associated with white matter hyperintensities (WMH) cross-sectionally, but its effect on WMH progression is uncertain. Methods: Participants in the Atherosclerosis Risk in Communities cohort study (n 5 10,924) completed a standardized headache questionnaire between 1993 and 1995. A subset of participants (n 5 1,028) received 2 MRIs 8 to 12 years apart: once at the time of headache ascertainment, and again from 2004 to 2006. WMH were quantified using both a visually graded score (0-9) and semiautomated volumetric analysis. Linear and logistic regression models adjusted for age, sex, and other vascular risk factors were constructed. Results: Individuals who had migraine without aura were cross-sectionally associated with an 87% greater odds of having a WMH score ≥3 than individuals without headache (adjusted odds ratio = 1.87;95% confidence interval [CI]: 1.04, 3.37). Participants with migraine had an average of 2. 65 cm3 more WMH than those without headache (95% CI: 0.06, 5.24). However, there was no significant difference in WMH progression over the study period between individuals with and without migraine (1.58 cm3 more progression for individuals with migraine compared to those without; 95% CI: 20.37, 3.53). Conclusion: Migraine is associated with WMH volume cross-sectionally but not with WMH progression over time. This suggests that the association between migraine and WMH is stable in older age and may be primarily attributable to changes occurring earlier in life, although further work is needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)1308-1313
Number of pages6
JournalNeurology
Volume81
Issue number15
DOIs
StatePublished - Oct 8 2013

Fingerprint

Migraine Disorders
Headache
Confidence Intervals
Logistic Models
Migraine without Aura
White Matter
Progression
Confidence Interval
Linear Models
Atherosclerosis
Cohort Studies
Odds Ratio

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Hamedani, A. G., Rose, K. M., Lee Peterlin, B., Mosley, T. H., Coker, L. H., Jack, C. R., ... Gottesman, R. F. (2013). Migraine and white matter hyperintensities: The ARIC MRI study. Neurology, 81(15), 1308-1313. https://doi.org/10.1212/WNL.0b013e3182a8235b

Migraine and white matter hyperintensities : The ARIC MRI study. / Hamedani, Ali G.; Rose, Kathryn M.; Lee Peterlin, B.; Mosley, Thomas H.; Coker, Laura H.; Jack, Clifford R.; Knopman, David S.; Alonso, Alvaro; Gottesman, Rebecca F.

In: Neurology, Vol. 81, No. 15, 08.10.2013, p. 1308-1313.

Research output: Contribution to journalArticle

Hamedani, AG, Rose, KM, Lee Peterlin, B, Mosley, TH, Coker, LH, Jack, CR, Knopman, DS, Alonso, A & Gottesman, RF 2013, 'Migraine and white matter hyperintensities: The ARIC MRI study', Neurology, vol. 81, no. 15, pp. 1308-1313. https://doi.org/10.1212/WNL.0b013e3182a8235b
Hamedani AG, Rose KM, Lee Peterlin B, Mosley TH, Coker LH, Jack CR et al. Migraine and white matter hyperintensities: The ARIC MRI study. Neurology. 2013 Oct 8;81(15):1308-1313. https://doi.org/10.1212/WNL.0b013e3182a8235b
Hamedani, Ali G. ; Rose, Kathryn M. ; Lee Peterlin, B. ; Mosley, Thomas H. ; Coker, Laura H. ; Jack, Clifford R. ; Knopman, David S. ; Alonso, Alvaro ; Gottesman, Rebecca F. / Migraine and white matter hyperintensities : The ARIC MRI study. In: Neurology. 2013 ; Vol. 81, No. 15. pp. 1308-1313.
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T2 - The ARIC MRI study

AU - Hamedani, Ali G.

AU - Rose, Kathryn M.

AU - Lee Peterlin, B.

AU - Mosley, Thomas H.

AU - Coker, Laura H.

AU - Jack, Clifford R.

AU - Knopman, David S.

AU - Alonso, Alvaro

AU - Gottesman, Rebecca F

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N2 - Objective: Migraine is associated with white matter hyperintensities (WMH) cross-sectionally, but its effect on WMH progression is uncertain. Methods: Participants in the Atherosclerosis Risk in Communities cohort study (n 5 10,924) completed a standardized headache questionnaire between 1993 and 1995. A subset of participants (n 5 1,028) received 2 MRIs 8 to 12 years apart: once at the time of headache ascertainment, and again from 2004 to 2006. WMH were quantified using both a visually graded score (0-9) and semiautomated volumetric analysis. Linear and logistic regression models adjusted for age, sex, and other vascular risk factors were constructed. Results: Individuals who had migraine without aura were cross-sectionally associated with an 87% greater odds of having a WMH score ≥3 than individuals without headache (adjusted odds ratio = 1.87;95% confidence interval [CI]: 1.04, 3.37). Participants with migraine had an average of 2. 65 cm3 more WMH than those without headache (95% CI: 0.06, 5.24). However, there was no significant difference in WMH progression over the study period between individuals with and without migraine (1.58 cm3 more progression for individuals with migraine compared to those without; 95% CI: 20.37, 3.53). Conclusion: Migraine is associated with WMH volume cross-sectionally but not with WMH progression over time. This suggests that the association between migraine and WMH is stable in older age and may be primarily attributable to changes occurring earlier in life, although further work is needed to confirm these findings.

AB - Objective: Migraine is associated with white matter hyperintensities (WMH) cross-sectionally, but its effect on WMH progression is uncertain. Methods: Participants in the Atherosclerosis Risk in Communities cohort study (n 5 10,924) completed a standardized headache questionnaire between 1993 and 1995. A subset of participants (n 5 1,028) received 2 MRIs 8 to 12 years apart: once at the time of headache ascertainment, and again from 2004 to 2006. WMH were quantified using both a visually graded score (0-9) and semiautomated volumetric analysis. Linear and logistic regression models adjusted for age, sex, and other vascular risk factors were constructed. Results: Individuals who had migraine without aura were cross-sectionally associated with an 87% greater odds of having a WMH score ≥3 than individuals without headache (adjusted odds ratio = 1.87;95% confidence interval [CI]: 1.04, 3.37). Participants with migraine had an average of 2. 65 cm3 more WMH than those without headache (95% CI: 0.06, 5.24). However, there was no significant difference in WMH progression over the study period between individuals with and without migraine (1.58 cm3 more progression for individuals with migraine compared to those without; 95% CI: 20.37, 3.53). Conclusion: Migraine is associated with WMH volume cross-sectionally but not with WMH progression over time. This suggests that the association between migraine and WMH is stable in older age and may be primarily attributable to changes occurring earlier in life, although further work is needed to confirm these findings.

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