Migraine and other headaches

Associations with Rose angina and coronary heart disease

K. M. Rose, A. P. Carson, C. P. Sanford, P. E. Stang, C. A. Brown, A. R. Folsom, Moyses Szklo

Research output: Contribution to journalArticle

Abstract

Objective: To examine the association between a lifetime history of migraines and other headaches with and without aura and Rose angina and coronary heart disease (CHD). Methods: Participants were 12,409 African American and white men and women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting ≥4 hours (migraine with aura, migraine without aura, other headaches with aura, other headaches without aura, no headaches). Gender-specific associations of headaches with Rose angina and CHD, adjusted for sociodemographic and cardiovascular disease risk factors, were evaluated using Poisson regression. Results: Participants with a history of migraines and other headaches were more likely to have a history of Rose angina than those without headaches. The associations were stronger for migraine and other headaches with aura (prevalence ratio [PR] = 3.0, 95% CI = 2.4, 3.7 and PR = 2.0, 95% CI = 1.5, 2.7 for women; PR = 2.2, 95% CI = 1.2, 3.9 and PR = 2.4, 95% CI = 1.4, 3.9 for men) than for migraine and other headaches without aura (PR = 1.5, 95% CI = 1.2, 1.9 and PR = 1.3, 95% CI = 1.1, 1.6 for women; PR = 1.9, 95% CI = 1.2, 2.9 and OR = 1.4, 95% CI = 1.0, 1.8 for men). In contrast, migraine and other headaches were not associated with CHD, regardless of the presence of aura. Conclusions: The lack of association of migraines with coronary heart disease suggests that the association of migraine with Rose angina is not related to coronary artery disease. Future research assessing other common underlying pathologic mechanisms is warranted.

Original languageEnglish (US)
Pages (from-to)2233-2239
Number of pages7
JournalNeurology
Volume63
Issue number12
StatePublished - Dec 28 2004

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Migraine Disorders
Coronary Disease
Headache
Epilepsy
Migraine with Aura
African Americans
Coronary Artery Disease
Atherosclerosis
Cardiovascular Diseases

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rose, K. M., Carson, A. P., Sanford, C. P., Stang, P. E., Brown, C. A., Folsom, A. R., & Szklo, M. (2004). Migraine and other headaches: Associations with Rose angina and coronary heart disease. Neurology, 63(12), 2233-2239.

Migraine and other headaches : Associations with Rose angina and coronary heart disease. / Rose, K. M.; Carson, A. P.; Sanford, C. P.; Stang, P. E.; Brown, C. A.; Folsom, A. R.; Szklo, Moyses.

In: Neurology, Vol. 63, No. 12, 28.12.2004, p. 2233-2239.

Research output: Contribution to journalArticle

Rose, KM, Carson, AP, Sanford, CP, Stang, PE, Brown, CA, Folsom, AR & Szklo, M 2004, 'Migraine and other headaches: Associations with Rose angina and coronary heart disease', Neurology, vol. 63, no. 12, pp. 2233-2239.
Rose KM, Carson AP, Sanford CP, Stang PE, Brown CA, Folsom AR et al. Migraine and other headaches: Associations with Rose angina and coronary heart disease. Neurology. 2004 Dec 28;63(12):2233-2239.
Rose, K. M. ; Carson, A. P. ; Sanford, C. P. ; Stang, P. E. ; Brown, C. A. ; Folsom, A. R. ; Szklo, Moyses. / Migraine and other headaches : Associations with Rose angina and coronary heart disease. In: Neurology. 2004 ; Vol. 63, No. 12. pp. 2233-2239.
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title = "Migraine and other headaches: Associations with Rose angina and coronary heart disease",
abstract = "Objective: To examine the association between a lifetime history of migraines and other headaches with and without aura and Rose angina and coronary heart disease (CHD). Methods: Participants were 12,409 African American and white men and women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting ≥4 hours (migraine with aura, migraine without aura, other headaches with aura, other headaches without aura, no headaches). Gender-specific associations of headaches with Rose angina and CHD, adjusted for sociodemographic and cardiovascular disease risk factors, were evaluated using Poisson regression. Results: Participants with a history of migraines and other headaches were more likely to have a history of Rose angina than those without headaches. The associations were stronger for migraine and other headaches with aura (prevalence ratio [PR] = 3.0, 95{\%} CI = 2.4, 3.7 and PR = 2.0, 95{\%} CI = 1.5, 2.7 for women; PR = 2.2, 95{\%} CI = 1.2, 3.9 and PR = 2.4, 95{\%} CI = 1.4, 3.9 for men) than for migraine and other headaches without aura (PR = 1.5, 95{\%} CI = 1.2, 1.9 and PR = 1.3, 95{\%} CI = 1.1, 1.6 for women; PR = 1.9, 95{\%} CI = 1.2, 2.9 and OR = 1.4, 95{\%} CI = 1.0, 1.8 for men). In contrast, migraine and other headaches were not associated with CHD, regardless of the presence of aura. Conclusions: The lack of association of migraines with coronary heart disease suggests that the association of migraine with Rose angina is not related to coronary artery disease. Future research assessing other common underlying pathologic mechanisms is warranted.",
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T2 - Associations with Rose angina and coronary heart disease

AU - Rose, K. M.

AU - Carson, A. P.

AU - Sanford, C. P.

AU - Stang, P. E.

AU - Brown, C. A.

AU - Folsom, A. R.

AU - Szklo, Moyses

PY - 2004/12/28

Y1 - 2004/12/28

N2 - Objective: To examine the association between a lifetime history of migraines and other headaches with and without aura and Rose angina and coronary heart disease (CHD). Methods: Participants were 12,409 African American and white men and women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting ≥4 hours (migraine with aura, migraine without aura, other headaches with aura, other headaches without aura, no headaches). Gender-specific associations of headaches with Rose angina and CHD, adjusted for sociodemographic and cardiovascular disease risk factors, were evaluated using Poisson regression. Results: Participants with a history of migraines and other headaches were more likely to have a history of Rose angina than those without headaches. The associations were stronger for migraine and other headaches with aura (prevalence ratio [PR] = 3.0, 95% CI = 2.4, 3.7 and PR = 2.0, 95% CI = 1.5, 2.7 for women; PR = 2.2, 95% CI = 1.2, 3.9 and PR = 2.4, 95% CI = 1.4, 3.9 for men) than for migraine and other headaches without aura (PR = 1.5, 95% CI = 1.2, 1.9 and PR = 1.3, 95% CI = 1.1, 1.6 for women; PR = 1.9, 95% CI = 1.2, 2.9 and OR = 1.4, 95% CI = 1.0, 1.8 for men). In contrast, migraine and other headaches were not associated with CHD, regardless of the presence of aura. Conclusions: The lack of association of migraines with coronary heart disease suggests that the association of migraine with Rose angina is not related to coronary artery disease. Future research assessing other common underlying pathologic mechanisms is warranted.

AB - Objective: To examine the association between a lifetime history of migraines and other headaches with and without aura and Rose angina and coronary heart disease (CHD). Methods: Participants were 12,409 African American and white men and women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting ≥4 hours (migraine with aura, migraine without aura, other headaches with aura, other headaches without aura, no headaches). Gender-specific associations of headaches with Rose angina and CHD, adjusted for sociodemographic and cardiovascular disease risk factors, were evaluated using Poisson regression. Results: Participants with a history of migraines and other headaches were more likely to have a history of Rose angina than those without headaches. The associations were stronger for migraine and other headaches with aura (prevalence ratio [PR] = 3.0, 95% CI = 2.4, 3.7 and PR = 2.0, 95% CI = 1.5, 2.7 for women; PR = 2.2, 95% CI = 1.2, 3.9 and PR = 2.4, 95% CI = 1.4, 3.9 for men) than for migraine and other headaches without aura (PR = 1.5, 95% CI = 1.2, 1.9 and PR = 1.3, 95% CI = 1.1, 1.6 for women; PR = 1.9, 95% CI = 1.2, 2.9 and OR = 1.4, 95% CI = 1.0, 1.8 for men). In contrast, migraine and other headaches were not associated with CHD, regardless of the presence of aura. Conclusions: The lack of association of migraines with coronary heart disease suggests that the association of migraine with Rose angina is not related to coronary artery disease. Future research assessing other common underlying pathologic mechanisms is warranted.

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