Migraine and obesity: Epidemiology, mechanisms, and implications

B. Lee Peterlin, Alan M. Rapoport, Tobias Kurth

Research output: Contribution to journalArticle

Abstract

Adipose tissue is a dynamic neuroendocrine organ that is involved in multiple physiological and pathological processes, and when excessive, results in obesity. Clinical and population-based data suggest that migraine and chronic daily headache are associated with obesity, as estimated by anthropometric indices. In addition, translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. In this article, we first review the definition and ascertainment of obesity. This is followed by a review of the clinical and population-based studies evaluating the associations between obesity and chronic daily headache and migraine. We then discuss the central and peripheral pathways involved in the regulation of feeding, where it overlaps with migraine pathophysiology, and where future research may be headed in light of these data.

Original languageEnglish (US)
Pages (from-to)631-648
Number of pages18
JournalHeadache
Volume50
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Migraine Disorders
Epidemiology
Obesity
Headache Disorders
Physiological Phenomena
Adipokines
Adiponectin
Pathologic Processes
Leptin
Population
Adipose Tissue
Serotonin
Peptides
Research

Keywords

  • Abdominal obesity
  • Adipocytokines
  • Adiponectin
  • BMI
  • Migraine
  • Obesity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Migraine and obesity : Epidemiology, mechanisms, and implications. / Peterlin, B. Lee; Rapoport, Alan M.; Kurth, Tobias.

In: Headache, Vol. 50, No. 4, 04.2010, p. 631-648.

Research output: Contribution to journalArticle

Peterlin, B. Lee ; Rapoport, Alan M. ; Kurth, Tobias. / Migraine and obesity : Epidemiology, mechanisms, and implications. In: Headache. 2010 ; Vol. 50, No. 4. pp. 631-648.
@article{34dd3136e4474239afbc49de42544c66,
title = "Migraine and obesity: Epidemiology, mechanisms, and implications",
abstract = "Adipose tissue is a dynamic neuroendocrine organ that is involved in multiple physiological and pathological processes, and when excessive, results in obesity. Clinical and population-based data suggest that migraine and chronic daily headache are associated with obesity, as estimated by anthropometric indices. In addition, translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. In this article, we first review the definition and ascertainment of obesity. This is followed by a review of the clinical and population-based studies evaluating the associations between obesity and chronic daily headache and migraine. We then discuss the central and peripheral pathways involved in the regulation of feeding, where it overlaps with migraine pathophysiology, and where future research may be headed in light of these data.",
keywords = "Abdominal obesity, Adipocytokines, Adiponectin, BMI, Migraine, Obesity",
author = "Peterlin, {B. Lee} and Rapoport, {Alan M.} and Tobias Kurth",
year = "2010",
month = "4",
doi = "10.1111/j.1526-4610.2009.01554.x",
language = "English (US)",
volume = "50",
pages = "631--648",
journal = "Headache",
issn = "0017-8748",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Migraine and obesity

T2 - Epidemiology, mechanisms, and implications

AU - Peterlin, B. Lee

AU - Rapoport, Alan M.

AU - Kurth, Tobias

PY - 2010/4

Y1 - 2010/4

N2 - Adipose tissue is a dynamic neuroendocrine organ that is involved in multiple physiological and pathological processes, and when excessive, results in obesity. Clinical and population-based data suggest that migraine and chronic daily headache are associated with obesity, as estimated by anthropometric indices. In addition, translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. In this article, we first review the definition and ascertainment of obesity. This is followed by a review of the clinical and population-based studies evaluating the associations between obesity and chronic daily headache and migraine. We then discuss the central and peripheral pathways involved in the regulation of feeding, where it overlaps with migraine pathophysiology, and where future research may be headed in light of these data.

AB - Adipose tissue is a dynamic neuroendocrine organ that is involved in multiple physiological and pathological processes, and when excessive, results in obesity. Clinical and population-based data suggest that migraine and chronic daily headache are associated with obesity, as estimated by anthropometric indices. In addition, translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. In this article, we first review the definition and ascertainment of obesity. This is followed by a review of the clinical and population-based studies evaluating the associations between obesity and chronic daily headache and migraine. We then discuss the central and peripheral pathways involved in the regulation of feeding, where it overlaps with migraine pathophysiology, and where future research may be headed in light of these data.

KW - Abdominal obesity

KW - Adipocytokines

KW - Adiponectin

KW - BMI

KW - Migraine

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=77950526065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950526065&partnerID=8YFLogxK

U2 - 10.1111/j.1526-4610.2009.01554.x

DO - 10.1111/j.1526-4610.2009.01554.x

M3 - Article

C2 - 19845784

AN - SCOPUS:77950526065

VL - 50

SP - 631

EP - 648

JO - Headache

JF - Headache

SN - 0017-8748

IS - 4

ER -