Microvessel quantification as a measure of angiogenic activity in benign breast tissue lesions: A marker for precancerous disease?

T. A. Fregene, C. M. Kellogg, K. J. Pienta

Research output: Contribution to journalArticle


Neovascularization is a key step in the transformation of normal breast tissue into a cancerous phenotype. We investigated the angiogenic activity of 58 cases of histologically confirmed benign breast lesions quantitating angiogenic activity by factor VIII highlighting of endothelial cells. The mean microvessel count (MVC) for all patients was 51 per 0.19 mm2 in the area of highest angiogenic activity at x400 magnification (range 21-113 per mm2). MVC in benign tissues were similar to those found previously in cancer tissues. These data suggest that the 'angiogenic switch' occurs early in breast transformation and that a role may exist for the use of MVC in the identification of persons at heightened risk for subsequent development of breast cancer.

Original languageEnglish (US)
Pages (from-to)1181-1184
Number of pages4
JournalOncology Reports
Issue number6
StatePublished - Jan 1 1995



  • Angiogenic activity
  • Breast tissue lesions
  • Microvessel quantification
  • Precancerous disease

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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