Abstract
Background: Trousseau's syndrome is a prothrombotic state associated with malignancy that is poorly understood pathophysiologically. Methodsand Results: Here we report studies on the blood of a 55-year-old man with giant-cell lung carcinoma who developed a severe form of Trousseau's syndrome. His clinical course was dominated by an extremely hypercoagulable state. Despite receiving potent antithrombotic therapy, he suffered eleven major arterial and venous thrombotic events over a 5 month period. We examined the patient's blood for tissue factor (TF), the major initiator of coagulation, and found its concentration in his plasma to be forty-one-fold higher than the mean concentration derived from testing of 16 normal individuals. Conclusion: Almost all of the TFin the patient's plasma was associated with cell-derived microvesicles, likely shed by the cancer cells.
Original language | English (US) |
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Pages (from-to) | 70-74 |
Number of pages | 5 |
Journal | Journal of Thrombosis and Haemostasis |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2007 |
Externally published | Yes |
Keywords
- Cancer
- Microvesicles
- Thrombosis
- Tissue factor
- Trousseau's syndrome
ASJC Scopus subject areas
- Hematology