Microvesicle-associated tissue factor and Trousseau's syndrome

I. Del Conde, Lavina Bharwani, D. J. Dietzen, U. Pendurthi, P. Thiagarajan, José A. López

Research output: Contribution to journalArticle

Abstract

Background: Trousseau's syndrome is a prothrombotic state associated with malignancy that is poorly understood pathophysiologically. Methodsand Results: Here we report studies on the blood of a 55-year-old man with giant-cell lung carcinoma who developed a severe form of Trousseau's syndrome. His clinical course was dominated by an extremely hypercoagulable state. Despite receiving potent antithrombotic therapy, he suffered eleven major arterial and venous thrombotic events over a 5 month period. We examined the patient's blood for tissue factor (TF), the major initiator of coagulation, and found its concentration in his plasma to be forty-one-fold higher than the mean concentration derived from testing of 16 normal individuals. Conclusion: Almost all of the TFin the patient's plasma was associated with cell-derived microvesicles, likely shed by the cancer cells.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalJournal of Thrombosis and Haemostasis
Volume5
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

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Thromboplastin
Giant Cell Carcinoma
Neoplasms
Lung
Therapeutics

Keywords

  • Cancer
  • Microvesicles
  • Thrombosis
  • Tissue factor
  • Trousseau's syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Microvesicle-associated tissue factor and Trousseau's syndrome. / Del Conde, I.; Bharwani, Lavina; Dietzen, D. J.; Pendurthi, U.; Thiagarajan, P.; López, José A.

In: Journal of Thrombosis and Haemostasis, Vol. 5, No. 1, 01.2007, p. 70-74.

Research output: Contribution to journalArticle

Del Conde, I, Bharwani, L, Dietzen, DJ, Pendurthi, U, Thiagarajan, P & López, JA 2007, 'Microvesicle-associated tissue factor and Trousseau's syndrome', Journal of Thrombosis and Haemostasis, vol. 5, no. 1, pp. 70-74. https://doi.org/10.1111/j.1538-7836.2006.02301.x
Del Conde, I. ; Bharwani, Lavina ; Dietzen, D. J. ; Pendurthi, U. ; Thiagarajan, P. ; López, José A. / Microvesicle-associated tissue factor and Trousseau's syndrome. In: Journal of Thrombosis and Haemostasis. 2007 ; Vol. 5, No. 1. pp. 70-74.
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