Microvascular oxygen consumption during sickle cell pain crisis

Carol A. Rowley, Allison K. Ikeda, Miles Seidel, Tiffany C. Anaebere, Matthew D. Antalek, Catherine Seamon, Anna K. Conrey, Laurel Mendelsohn, James Nichols, Alexander M. Gorbach, Gregory J. Kato, Hans Ackerman

Research output: Contribution to journalArticle

Abstract

Sickle cell disease is an inherited blood disorder characterized by chronic hemolytic anemia and episodic vaso-occlusive pain crises. Vaso-occlusion occurs when deoxygenated hemoglobin S polymerizes and erythrocytes sickle and adhere in the microvasculature, a process dependent on the concentration of hemoglobin S and the rate of deoxygenation, among other factors. We measured oxygen consumption in the thenar eminence during brachial artery occlusion in sickle cell patients and healthy individuals. Microvascular oxygen consumption was greater in sickle cell patients than in healthy individuals (median [interquartile range]; sickle cell: 0.91 [0.75-1.07] vs healthy: 0.75 [0.62-0.94] -ΔHbO2/min, P <.05) and was elevated further during acute pain crisis (crisis: 1.10 [0.78-1.30] vs recovered: 0.88 [0.76-1.03] -ΔHbO2/min, P <.05). Increased microvascular oxygen consumption during pain crisis could affect the local oxygen saturation of hemoglobin when oxygen delivery is limiting. Identifying the mechanisms of elevated oxygen consumption during pain crisis might lead to the development of new therapeutic interventions. This trial was registered at www.clinicaltrials. gov as #NCT01568710.

Original languageEnglish (US)
Pages (from-to)3101-3104
Number of pages4
JournalBlood
Volume123
Issue number20
DOIs
StatePublished - May 15 2014
Externally publishedYes

Fingerprint

Oxygen Consumption
Oxygen
Sickle Hemoglobin
Pain
Brachial Artery
Hemolytic Anemia
Acute Pain
Sickle Cell Anemia
Microvessels
Hemoglobins
Erythrocytes
Blood
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Rowley, C. A., Ikeda, A. K., Seidel, M., Anaebere, T. C., Antalek, M. D., Seamon, C., ... Ackerman, H. (2014). Microvascular oxygen consumption during sickle cell pain crisis. Blood, 123(20), 3101-3104. https://doi.org/10.1182/blood-2013-11-533406

Microvascular oxygen consumption during sickle cell pain crisis. / Rowley, Carol A.; Ikeda, Allison K.; Seidel, Miles; Anaebere, Tiffany C.; Antalek, Matthew D.; Seamon, Catherine; Conrey, Anna K.; Mendelsohn, Laurel; Nichols, James; Gorbach, Alexander M.; Kato, Gregory J.; Ackerman, Hans.

In: Blood, Vol. 123, No. 20, 15.05.2014, p. 3101-3104.

Research output: Contribution to journalArticle

Rowley, CA, Ikeda, AK, Seidel, M, Anaebere, TC, Antalek, MD, Seamon, C, Conrey, AK, Mendelsohn, L, Nichols, J, Gorbach, AM, Kato, GJ & Ackerman, H 2014, 'Microvascular oxygen consumption during sickle cell pain crisis', Blood, vol. 123, no. 20, pp. 3101-3104. https://doi.org/10.1182/blood-2013-11-533406
Rowley CA, Ikeda AK, Seidel M, Anaebere TC, Antalek MD, Seamon C et al. Microvascular oxygen consumption during sickle cell pain crisis. Blood. 2014 May 15;123(20):3101-3104. https://doi.org/10.1182/blood-2013-11-533406
Rowley, Carol A. ; Ikeda, Allison K. ; Seidel, Miles ; Anaebere, Tiffany C. ; Antalek, Matthew D. ; Seamon, Catherine ; Conrey, Anna K. ; Mendelsohn, Laurel ; Nichols, James ; Gorbach, Alexander M. ; Kato, Gregory J. ; Ackerman, Hans. / Microvascular oxygen consumption during sickle cell pain crisis. In: Blood. 2014 ; Vol. 123, No. 20. pp. 3101-3104.
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