Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction

Carlos E. Rochitte, Raymond J. Kim, Hanns B. Hillenbrand, Enn Ling Chen, Joao Lima

Research output: Contribution to journalArticle

Abstract

Loss of membrane permeability caused by ischemia leads to cellular sodium accumulation and myocardial edema. This phenomenon has important implications to left ventricular structure and function in the first hours after myocardial infarction. We hypothesized that during this period of time, after prolonged coronary occlusion and complete reflow, the rate of myocardial sodium accumulation is governed by microvascular integrity. We used 3-dimensional 23Na MRI to monitor myocardial sodium content changes over time in an in vivo closed-chest canine model (n=13) of myocardial infarction and reperfusion. Infarcts with microvascular obstruction (MO) defined by both radioactive microspheres and contrast-enhanced 1H MRI showed a slower rate of sodium accumulation as well as lower blood flow at 20 minutes and 6 hours after reperfusion. Conversely, the absence of MO was associated with faster rates of sodium accumulation and greater blood flow restoration. In addition, infarct size by 23Na MRI correlated best with infarct size by triphenyltetrazolium chloride and contrast-enhanced 1H MRI at 9 hours after reperfusion. We conclude that in reperfused myocardial infarction, sodium accumulation is dependent on microvascular integrity and is slower in regions of MO compared with those with patent microvasculature. Finally, 23Na MRI can be a useful tool for monitoring in vivo myocardial sodium content in acute myocardial infarction.

Original languageEnglish (US)
Pages (from-to)648-655
Number of pages8
JournalCirculation Research
Volume87
Issue number8
StatePublished - Oct 13 2000

Fingerprint

Infarction
Sodium
Myocardial Infarction
Reperfusion
Myocardial Reperfusion
Coronary Occlusion
Microvessels
Microspheres
Left Ventricular Function
Canidae
Permeability
Edema
Thorax
Ischemia
Membranes

Keywords

  • Magnetic resonance imaging
  • Microcirculation
  • Myocardial infarction
  • Reperfusion
  • Sodium

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Rochitte, C. E., Kim, R. J., Hillenbrand, H. B., Chen, E. L., & Lima, J. (2000). Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction. Circulation Research, 87(8), 648-655.

Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction. / Rochitte, Carlos E.; Kim, Raymond J.; Hillenbrand, Hanns B.; Chen, Enn Ling; Lima, Joao.

In: Circulation Research, Vol. 87, No. 8, 13.10.2000, p. 648-655.

Research output: Contribution to journalArticle

Rochitte, CE, Kim, RJ, Hillenbrand, HB, Chen, EL & Lima, J 2000, 'Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction', Circulation Research, vol. 87, no. 8, pp. 648-655.
Rochitte, Carlos E. ; Kim, Raymond J. ; Hillenbrand, Hanns B. ; Chen, Enn Ling ; Lima, Joao. / Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction. In: Circulation Research. 2000 ; Vol. 87, No. 8. pp. 648-655.
@article{a5834f2d02b84b87b8cbad9faaa9406c,
title = "Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction",
abstract = "Loss of membrane permeability caused by ischemia leads to cellular sodium accumulation and myocardial edema. This phenomenon has important implications to left ventricular structure and function in the first hours after myocardial infarction. We hypothesized that during this period of time, after prolonged coronary occlusion and complete reflow, the rate of myocardial sodium accumulation is governed by microvascular integrity. We used 3-dimensional 23Na MRI to monitor myocardial sodium content changes over time in an in vivo closed-chest canine model (n=13) of myocardial infarction and reperfusion. Infarcts with microvascular obstruction (MO) defined by both radioactive microspheres and contrast-enhanced 1H MRI showed a slower rate of sodium accumulation as well as lower blood flow at 20 minutes and 6 hours after reperfusion. Conversely, the absence of MO was associated with faster rates of sodium accumulation and greater blood flow restoration. In addition, infarct size by 23Na MRI correlated best with infarct size by triphenyltetrazolium chloride and contrast-enhanced 1H MRI at 9 hours after reperfusion. We conclude that in reperfused myocardial infarction, sodium accumulation is dependent on microvascular integrity and is slower in regions of MO compared with those with patent microvasculature. Finally, 23Na MRI can be a useful tool for monitoring in vivo myocardial sodium content in acute myocardial infarction.",
keywords = "Magnetic resonance imaging, Microcirculation, Myocardial infarction, Reperfusion, Sodium",
author = "Rochitte, {Carlos E.} and Kim, {Raymond J.} and Hillenbrand, {Hanns B.} and Chen, {Enn Ling} and Joao Lima",
year = "2000",
month = "10",
day = "13",
language = "English (US)",
volume = "87",
pages = "648--655",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction

AU - Rochitte, Carlos E.

AU - Kim, Raymond J.

AU - Hillenbrand, Hanns B.

AU - Chen, Enn Ling

AU - Lima, Joao

PY - 2000/10/13

Y1 - 2000/10/13

N2 - Loss of membrane permeability caused by ischemia leads to cellular sodium accumulation and myocardial edema. This phenomenon has important implications to left ventricular structure and function in the first hours after myocardial infarction. We hypothesized that during this period of time, after prolonged coronary occlusion and complete reflow, the rate of myocardial sodium accumulation is governed by microvascular integrity. We used 3-dimensional 23Na MRI to monitor myocardial sodium content changes over time in an in vivo closed-chest canine model (n=13) of myocardial infarction and reperfusion. Infarcts with microvascular obstruction (MO) defined by both radioactive microspheres and contrast-enhanced 1H MRI showed a slower rate of sodium accumulation as well as lower blood flow at 20 minutes and 6 hours after reperfusion. Conversely, the absence of MO was associated with faster rates of sodium accumulation and greater blood flow restoration. In addition, infarct size by 23Na MRI correlated best with infarct size by triphenyltetrazolium chloride and contrast-enhanced 1H MRI at 9 hours after reperfusion. We conclude that in reperfused myocardial infarction, sodium accumulation is dependent on microvascular integrity and is slower in regions of MO compared with those with patent microvasculature. Finally, 23Na MRI can be a useful tool for monitoring in vivo myocardial sodium content in acute myocardial infarction.

AB - Loss of membrane permeability caused by ischemia leads to cellular sodium accumulation and myocardial edema. This phenomenon has important implications to left ventricular structure and function in the first hours after myocardial infarction. We hypothesized that during this period of time, after prolonged coronary occlusion and complete reflow, the rate of myocardial sodium accumulation is governed by microvascular integrity. We used 3-dimensional 23Na MRI to monitor myocardial sodium content changes over time in an in vivo closed-chest canine model (n=13) of myocardial infarction and reperfusion. Infarcts with microvascular obstruction (MO) defined by both radioactive microspheres and contrast-enhanced 1H MRI showed a slower rate of sodium accumulation as well as lower blood flow at 20 minutes and 6 hours after reperfusion. Conversely, the absence of MO was associated with faster rates of sodium accumulation and greater blood flow restoration. In addition, infarct size by 23Na MRI correlated best with infarct size by triphenyltetrazolium chloride and contrast-enhanced 1H MRI at 9 hours after reperfusion. We conclude that in reperfused myocardial infarction, sodium accumulation is dependent on microvascular integrity and is slower in regions of MO compared with those with patent microvasculature. Finally, 23Na MRI can be a useful tool for monitoring in vivo myocardial sodium content in acute myocardial infarction.

KW - Magnetic resonance imaging

KW - Microcirculation

KW - Myocardial infarction

KW - Reperfusion

KW - Sodium

UR - http://www.scopus.com/inward/record.url?scp=0034644560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034644560&partnerID=8YFLogxK

M3 - Article

VL - 87

SP - 648

EP - 655

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 8

ER -