Microvascular aspects of acquired immune deficiency syndrome retinopathy

David A. Newsome; W. Richard Green; Earl D. Miller; Lou Ann Kiessling; Basil Morgan; Douglas A. Jabs; B. Frank Polk

doi:10.1016/0002-9394(84)90245-9

Microvascular aspects of acquired immune deficiency syndrome retinopathy

David A. Newsome, W. Richard Green, Earl D. Miller, Lou Ann Kiessling, Basil Morgan, Douglas A. Jabs, B. Frank Polk

Research output: Contribution to journal › Article › peer-review

Abstract

Twelve of 13 patients with the acquired immune deficiency syndrome exhibited ophthalmoscopically detectable retinal findings, including cotton-wool spots, hemorrhages, Roth spots, and microvascular changes. When we used fluorescein angiography, we detected focal nonperfusion and microvascular changes in all 13 of our patients. Most patients had no visual complaints unless they had cytomegalovirus involvement of the optic papilla or the central retina. One patient lost central visual acuity from loss of perfusion in a portion of his perifoveal capillary net. Histopathologic studies demonstrated the loss of retinal capillary cells and focal occlusions of small vessels. Retinal vessel walls were also thickened with PAS-positive material.

Original language	English (US)
Pages (from-to)	590-601
Number of pages	12
Journal	American journal of ophthalmology
Volume	98
Issue number	5
DOIs	https://doi.org/10.1016/0002-9394(84)90245-9
State	Published - Nov 1984

ASJC Scopus subject areas

Ophthalmology

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@article{d659a41f036e48dd802af31580a97efe,

title = "Microvascular aspects of acquired immune deficiency syndrome retinopathy",

abstract = "Twelve of 13 patients with the acquired immune deficiency syndrome exhibited ophthalmoscopically detectable retinal findings, including cotton-wool spots, hemorrhages, Roth spots, and microvascular changes. When we used fluorescein angiography, we detected focal nonperfusion and microvascular changes in all 13 of our patients. Most patients had no visual complaints unless they had cytomegalovirus involvement of the optic papilla or the central retina. One patient lost central visual acuity from loss of perfusion in a portion of his perifoveal capillary net. Histopathologic studies demonstrated the loss of retinal capillary cells and focal occlusions of small vessels. Retinal vessel walls were also thickened with PAS-positive material.",

author = "Newsome, {David A.} and Green, {W. Richard} and Miller, {Earl D.} and Kiessling, {Lou Ann} and Basil Morgan and Jabs, {Douglas A.} and Polk, {B. Frank}",

note = "Funding Information: From the Wilmer Institute, Department of Ophthalmology, Johns Hopkins Hospital and University, and the Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland. This study was supported in part by grant 5M01RR00722 from the National Institutes of Health. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1984",

month = nov,

doi = "10.1016/0002-9394(84)90245-9",

language = "English (US)",

volume = "98",

pages = "590--601",

journal = "American Journal of Ophthalmology",

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T1 - Microvascular aspects of acquired immune deficiency syndrome retinopathy

AU - Newsome, David A.

AU - Green, W. Richard

AU - Miller, Earl D.

AU - Kiessling, Lou Ann

AU - Morgan, Basil

AU - Jabs, Douglas A.

AU - Polk, B. Frank

N1 - Funding Information: From the Wilmer Institute, Department of Ophthalmology, Johns Hopkins Hospital and University, and the Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland. This study was supported in part by grant 5M01RR00722 from the National Institutes of Health. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1984/11

Y1 - 1984/11

N2 - Twelve of 13 patients with the acquired immune deficiency syndrome exhibited ophthalmoscopically detectable retinal findings, including cotton-wool spots, hemorrhages, Roth spots, and microvascular changes. When we used fluorescein angiography, we detected focal nonperfusion and microvascular changes in all 13 of our patients. Most patients had no visual complaints unless they had cytomegalovirus involvement of the optic papilla or the central retina. One patient lost central visual acuity from loss of perfusion in a portion of his perifoveal capillary net. Histopathologic studies demonstrated the loss of retinal capillary cells and focal occlusions of small vessels. Retinal vessel walls were also thickened with PAS-positive material.

AB - Twelve of 13 patients with the acquired immune deficiency syndrome exhibited ophthalmoscopically detectable retinal findings, including cotton-wool spots, hemorrhages, Roth spots, and microvascular changes. When we used fluorescein angiography, we detected focal nonperfusion and microvascular changes in all 13 of our patients. Most patients had no visual complaints unless they had cytomegalovirus involvement of the optic papilla or the central retina. One patient lost central visual acuity from loss of perfusion in a portion of his perifoveal capillary net. Histopathologic studies demonstrated the loss of retinal capillary cells and focal occlusions of small vessels. Retinal vessel walls were also thickened with PAS-positive material.

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Microvascular aspects of acquired immune deficiency syndrome retinopathy

Abstract

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