Microstructural white matter changes in carriers of the DYT1 gene mutation

Maren Carbon, Peter B. Kingsley, Sherwin Su, Gwenn S. Smith, Phoebe Spetsieris, Susan Bressman, David Eidelberg

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that the DYT1 genotype is associated with a disorder of anatomical connectivity involving primarily the sensorimotor cortex. We used diffusion tensor magnetic resonance imaging (DTI) to assess the microstructure of white matter pathways in mutation carriers and control subjects. Fractional anisotropy (FA), a measure of axonal integrity and coherence, was reduced (p < 0.005) in the subgyral white matter of the sensorimotor cortex of DYT1 carriers. Abnormal anatomical connectivity of the supplementary motor area may contribute to the susceptibility of DYT1 carriers to develop clinical manifestations of dystonia.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalAnnals of neurology
Volume56
Issue number2
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Microstructural white matter changes in carriers of the DYT1 gene mutation'. Together they form a unique fingerprint.

  • Cite this

    Carbon, M., Kingsley, P. B., Su, S., Smith, G. S., Spetsieris, P., Bressman, S., & Eidelberg, D. (2004). Microstructural white matter changes in carriers of the DYT1 gene mutation. Annals of neurology, 56(2), 283-286. https://doi.org/10.1002/ana.20177