Microscopic viscoelasticity of CF sputum determined by high-resolution nanoparticle tracking

Michelle Dawson, Denis Wirtz, Justin Hanes

Research output: Contribution to conferencePaperpeer-review


The quantitative statistical analysis of the individual particle transport rates in cystic fibrosis (CF) sputum was presented. It was found that in the microscopic domain, the particle diffuses freely in the interstitial fluid present in mucus pores. The interstitial viscosity of the mucus pores, the heterogeneities in particle transport and the bulk-fluid viscoelasticity were characterized. The results show that the technique is powerful for characterizing gene and drug carrier transport through mucus barriers and offers a accurate way to determine the rheological properties of small volumes of mucus from human patients or small animals.

Original languageEnglish (US)
Number of pages2
StatePublished - Dec 1 2004
Externally publishedYes
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004


Other2004 AIChE Annual Meeting
Country/TerritoryUnited States
CityAustin, TX

ASJC Scopus subject areas

  • Engineering(all)


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