Microsatellite instability occurs frequently in human gastric carcinoma

M. G. Rhyu, W. S. Park, Stephen Meltzer

Research output: Contribution to journalArticle

Abstract

Microsatellites are short repeated oligonucleotide sequences found throughout the human genome. Microsatellite instability has been reported in hereditary and sporadic colorectal carcinomas. Since gastric carcinoma shares numerous molecular abnormalities with colon cancer, we evaluated 52 gastric adenocarcinomas and adjacent dysplastic tissues for microsatellite instability at five chromosomal loci. Instability at one or more loci was observed in 16 (31%) of the 52 tumors, but in only two dysplastic tissues adjacent to their respective tumors. These results demonstrate that microsatellite instability is not limited to colorectal carcinoma, but also occurs frequently in another cancer, that of the stomach. It is probably a late event, developing only rarely in premalignant dysplastic lesions.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalOncogene
Volume9
Issue number1
StatePublished - 1994
Externally publishedYes

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Microsatellite Instability
Stomach
Carcinoma
Colorectal Neoplasms
Human Genome
Oligonucleotides
Microsatellite Repeats
Colonic Neoplasms
Stomach Neoplasms
Neoplasms
Adenocarcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Microsatellite instability occurs frequently in human gastric carcinoma. / Rhyu, M. G.; Park, W. S.; Meltzer, Stephen.

In: Oncogene, Vol. 9, No. 1, 1994, p. 29-32.

Research output: Contribution to journalArticle

Rhyu, M. G. ; Park, W. S. ; Meltzer, Stephen. / Microsatellite instability occurs frequently in human gastric carcinoma. In: Oncogene. 1994 ; Vol. 9, No. 1. pp. 29-32.
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