TY - JOUR
T1 - Microsatellite Instability Is Infrequent in Neuroblastoma
AU - Berg, Patricia E.
AU - Liu, Jinbo
AU - Frantz, Christopher N.
AU - Yin, Jing
AU - Rhyu, Mun Gan
AU - Meitzer, Stephen J.
PY - 1995/12/1
Y1 - 1995/12/1
N2 - Neuroblastoma (NB) is a childhood cancer of the autonomic nervous System. The molecular pathology of NB is not yet well understood. Both amplification of the proto-oncogene N-myc and loss of heterozygosity of several chromosomal loci occur in NB, representing genetic instability. In this study, we examined another type of genetic instability, microsatellite instability. Five chromosomal loci known to exhibit this alteration in colon, gastric, and pancreatic cancers were used in a PCR-based assay to examine 30 matched normal and tumor DNAs, which included all stages of tumor Progression. Among these 30, only 2 (7%) manifested microsatellite instability. There was no correlation between the occurrence of microsatellite instability and the amplification of the N-myc gene. These data show that microsatellite instability is infrequent in neuroblastoma tumors.
AB - Neuroblastoma (NB) is a childhood cancer of the autonomic nervous System. The molecular pathology of NB is not yet well understood. Both amplification of the proto-oncogene N-myc and loss of heterozygosity of several chromosomal loci occur in NB, representing genetic instability. In this study, we examined another type of genetic instability, microsatellite instability. Five chromosomal loci known to exhibit this alteration in colon, gastric, and pancreatic cancers were used in a PCR-based assay to examine 30 matched normal and tumor DNAs, which included all stages of tumor Progression. Among these 30, only 2 (7%) manifested microsatellite instability. There was no correlation between the occurrence of microsatellite instability and the amplification of the N-myc gene. These data show that microsatellite instability is infrequent in neuroblastoma tumors.
UR - http://www.scopus.com/inward/record.url?scp=0028784812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028784812&partnerID=8YFLogxK
M3 - Article
C2 - 8634665
AN - SCOPUS:0028784812
SN - 1055-9965
VL - 4
SP - 907
EP - 909
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 8
ER -