Microsatellite Instability Is Infrequent in Neuroblastoma

Patricia E. Berg, Jinbo Liu, Christopher N. Frantz, Jing Yin, Mun Gan Rhyu, Stephen J. Meitzer

Research output: Contribution to journalArticle

Abstract

Neuroblastoma (NB) is a childhood cancer of the autonomic nervous System. The molecular pathology of NB is not yet well understood. Both amplification of the proto-oncogene N-myc and loss of heterozygosity of several chromosomal loci occur in NB, representing genetic instability. In this study, we examined another type of genetic instability, microsatellite instability. Five chromosomal loci known to exhibit this alteration in colon, gastric, and pancreatic cancers were used in a PCR-based assay to examine 30 matched normal and tumor DNAs, which included all stages of tumor Progression. Among these 30, only 2 (7%) manifested microsatellite instability. There was no correlation between the occurrence of microsatellite instability and the amplification of the N-myc gene. These data show that microsatellite instability is infrequent in neuroblastoma tumors.

Original languageEnglish (US)
Pages (from-to)907-909
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume4
Issue number8
StatePublished - Dec 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Fingerprint Dive into the research topics of 'Microsatellite Instability Is Infrequent in Neuroblastoma'. Together they form a unique fingerprint.

  • Cite this

    Berg, P. E., Liu, J., Frantz, C. N., Yin, J., Rhyu, M. G., & Meitzer, S. J. (1995). Microsatellite Instability Is Infrequent in Neuroblastoma. Cancer Epidemiology Biomarkers and Prevention, 4(8), 907-909.