Microsatellite instability in primary neoplasms from HIV+ patients

Gauri C. Bedi, William H. Westra, Homayoon Farzadegan, Paula M. Pitha, David Sidransky

Research output: Contribution to journalArticle

Abstract

AIDS is associated with a high risk of certain malignancies, notably Kaposi's sarcoma (KS) and B-cell non-Hodgkin's lymphoma (NHL). The pathogenesis of these malignancies is not fully understood. One mechanism of malignant transformation recently described in colon tumorigenesis results from defects in DMA mismatch repair, manifest as widespread microsatellite instability. We demonstrate a high rate of microsatellite instability in KS and aggressive lymphomas obtained from HIV-infected patients, whereas there is no evidence of instability in similar lesions from HIV-negative patients. Further elucidation of the underlying mechanisms responsible for HIV-associated instability in primary tumours may provide insight into the pathogenesis of these AIDS-related neoplasms.

Original languageEnglish (US)
Pages (from-to)65-68
Number of pages4
JournalNature medicine
Volume1
Issue number1
DOIs
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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