Microsatellite evolution — evidence for directionality and variation in rate between species

David C. Rubinsztein, William Amos, Jayne Leggo, Sandy Goodburn, Sanjeev Jain, Shi Hua Li, Russell L. Margolis, Christopher A. Ross, Malcolm A. Ferguson-Smith

Research output: Contribution to journalArticle

Abstract

Microsatellite DMA sequences are rapidly becoming the dominant source of nuclear genetic markers for a wide range of applications, from genome mapping to forensic testing to population studies. If misinterpretation is to be avoided, it is vital that we understand fully the way in which microsatellite sequences evolve. We have therefore compared allele length distributions for 42 microsatellites in humans with their homologues in a range of related primates. We find a highly significant trend for the loci to be longer in humans, showing that microsatellites can evolve directionally and at different rates in closely related species.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalNature genetics
Volume10
Issue number3
DOIs
StatePublished - Jul 1995

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ASJC Scopus subject areas

  • Genetics

Cite this

Rubinsztein, D. C., Amos, W., Leggo, J., Goodburn, S., Jain, S., Li, S. H., Margolis, R. L., Ross, C. A., & Ferguson-Smith, M. A. (1995). Microsatellite evolution — evidence for directionality and variation in rate between species. Nature genetics, 10(3), 337-343. https://doi.org/10.1038/ng0795-337