MicroRNAs in stress signaling and human disease

Joshua T. Mendell; Eric N. Olson

doi:10.1016/j.cell.2012.02.005

MicroRNAs in stress signaling and human disease

Joshua T. Mendell, Eric N. Olson

Research output: Contribution to journal › Review article › peer-review

1150 Scopus citations

Abstract

Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

Original language	English (US)
Pages (from-to)	1172-1187
Number of pages	16
Journal	Cell
Volume	148
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2012.02.005
State	Published - Mar 16 2012
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2012.02.005

Cite this

@article{d81acfe3329549ed9e3d36302bf5a182,

title = "MicroRNAs in stress signaling and human disease",

abstract = "Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.",

author = "Mendell, {Joshua T.} and Olson, {Eric N.}",

note = "Funding Information: We thank Kathryn O'Donnell and members of the Mendell and Olson laboratories for helpful comments on the manuscript. J.T.M. is supported by the Cancer Prevention and Research Institute of Texas (CPRIT) and the National Institutes of Health (NIH) (R01CA120185 and P01CA134292). E.N.O. is supported by grants from the NIH (R01HL77439, R01HL093039, and U01HL100401), the Robert A. Welch Foundation, the American Heart Association-Jon Holden DeHaan Foundation, the D.W. Reynolds Center for Clinical Cardiovascular Research, the Leducq Transatlantic Network of Excellence in Cardiovascular Research Program, and CPRIT. E.N.O. is a cofounder and member of the Scientific Advisory Board of miRagen Therapeutics and holds equity in the company.",

year = "2012",

month = mar,

day = "16",

doi = "10.1016/j.cell.2012.02.005",

language = "English (US)",

volume = "148",

pages = "1172--1187",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - MicroRNAs in stress signaling and human disease

AU - Mendell, Joshua T.

AU - Olson, Eric N.

N1 - Funding Information: We thank Kathryn O'Donnell and members of the Mendell and Olson laboratories for helpful comments on the manuscript. J.T.M. is supported by the Cancer Prevention and Research Institute of Texas (CPRIT) and the National Institutes of Health (NIH) (R01CA120185 and P01CA134292). E.N.O. is supported by grants from the NIH (R01HL77439, R01HL093039, and U01HL100401), the Robert A. Welch Foundation, the American Heart Association-Jon Holden DeHaan Foundation, the D.W. Reynolds Center for Clinical Cardiovascular Research, the Leducq Transatlantic Network of Excellence in Cardiovascular Research Program, and CPRIT. E.N.O. is a cofounder and member of the Scientific Advisory Board of miRagen Therapeutics and holds equity in the company.

PY - 2012/3/16

Y1 - 2012/3/16

N2 - Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

AB - Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=84858379476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858379476&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2012.02.005

DO - 10.1016/j.cell.2012.02.005

M3 - Review article

C2 - 22424228

AN - SCOPUS:84858379476

SN - 0092-8674

VL - 148

SP - 1172

EP - 1187

JO - Cell

JF - Cell

IS - 6

ER -

MicroRNAs in stress signaling and human disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this