MicroRNAs in stress signaling and human disease

Joshua T. Mendell, Eric N. Olson

Research output: Contribution to journalReview articlepeer-review

Abstract

Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

Original languageEnglish (US)
Pages (from-to)1172-1187
Number of pages16
JournalCell
Volume148
Issue number6
DOIs
StatePublished - Mar 16 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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