MicroRNAs in cell proliferation, cell death, and tumorigenesis

H. W. Hwang, J. T. Mendell

Research output: Contribution to journalShort survey

Abstract

MicroRNAs (miRNAs) are a recently discovered class of ∼ 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.

Original languageEnglish (US)
Pages (from-to)776-780
Number of pages5
JournalBritish journal of cancer
Volume94
Issue number6
DOIs
StatePublished - Mar 27 2006

Keywords

  • Apoptosis
  • Cellular proliferation
  • MicroRNAs
  • Oncogene
  • Tumour suppressor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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