MicroRNAs: Expression, avoidance and subversion by vertebrate viruses

Peter Sarnow; Catherine L. Jopling; Kara L. Norman; Sylvia Schütz; Karen A. Wehner

doi:10.1038/nrmicro1473

MicroRNAs: Expression, avoidance and subversion by vertebrate viruses

Peter Sarnow, Catherine L. Jopling, Kara L. Norman, Sylvia Schütz, Karen A. Wehner

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

MicroRNAs (miRNAs), which can be expressed in a cell-type and tissue-specific manner, can influence the activities of genes that control cell growth and differentiation. Viruses often have clear tissue tropisms, raising the possibility that cellular miRNAs might modulate their pathogenesis. In this Review, we discuss recent findings that some vertebrate viruses either encode miRNAs or subvert cellular miRNAs, and that these miRNAs participate in both the infectious and the latent phase of the viral life cycle.

Original language	English (US)
Pages (from-to)	651-659
Number of pages	9
Journal	Nature Reviews Microbiology
Volume	4
Issue number	9
DOIs	https://doi.org/10.1038/nrmicro1473
State	Published - Sep 2006
Externally published	Yes

ASJC Scopus subject areas

Microbiology
General Immunology and Microbiology
Infectious Diseases

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10.1038/nrmicro1473

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title = "MicroRNAs: Expression, avoidance and subversion by vertebrate viruses",

abstract = "MicroRNAs (miRNAs), which can be expressed in a cell-type and tissue-specific manner, can influence the activities of genes that control cell growth and differentiation. Viruses often have clear tissue tropisms, raising the possibility that cellular miRNAs might modulate their pathogenesis. In this Review, we discuss recent findings that some vertebrate viruses either encode miRNAs or subvert cellular miRNAs, and that these miRNAs participate in both the infectious and the latent phase of the viral life cycle.",

author = "Peter Sarnow and Jopling, {Catherine L.} and Norman, {Kara L.} and Sylvia Sch{\"u}tz and Wehner, {Karen A.}",

note = "Funding Information: Work in the authors{\textquoteright} laboratory was supported by grants from the National Institutes of Health (USA), the Alberta Heritage Foundation for Medical Research (Canada) (to K.L.N.) and the Damon Runyon Cancer Research Foundation (USA) (to K.A.W.).",

year = "2006",

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AU - Sarnow, Peter

AU - Jopling, Catherine L.

AU - Norman, Kara L.

AU - Schütz, Sylvia

AU - Wehner, Karen A.

N1 - Funding Information: Work in the authors’ laboratory was supported by grants from the National Institutes of Health (USA), the Alberta Heritage Foundation for Medical Research (Canada) (to K.L.N.) and the Damon Runyon Cancer Research Foundation (USA) (to K.A.W.).

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N2 - MicroRNAs (miRNAs), which can be expressed in a cell-type and tissue-specific manner, can influence the activities of genes that control cell growth and differentiation. Viruses often have clear tissue tropisms, raising the possibility that cellular miRNAs might modulate their pathogenesis. In this Review, we discuss recent findings that some vertebrate viruses either encode miRNAs or subvert cellular miRNAs, and that these miRNAs participate in both the infectious and the latent phase of the viral life cycle.

AB - MicroRNAs (miRNAs), which can be expressed in a cell-type and tissue-specific manner, can influence the activities of genes that control cell growth and differentiation. Viruses often have clear tissue tropisms, raising the possibility that cellular miRNAs might modulate their pathogenesis. In this Review, we discuss recent findings that some vertebrate viruses either encode miRNAs or subvert cellular miRNAs, and that these miRNAs participate in both the infectious and the latent phase of the viral life cycle.

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MicroRNAs: Expression, avoidance and subversion by vertebrate viruses

Abstract

ASJC Scopus subject areas

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