MicroRNAs and energy metabolism in cancer cells

Linchong Sun, Xiaoping He, Yang Cao, Ping Gao, Huafeng Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In 1927, Otto Warburg demonstrated that cancer cells use glucose for growth and division in a manner that is different from normal cells, a phenomenon known nowadays as Warburg Effect. To date, overwhelming evidence indicates that aberration in metabolism plays important roles in cancer progression. More recently, for more than a decade biologists are fascinated by the functions of small RNAs known as microRNAs (miRNAs), which play vital roles in many important biological processes, such as cell proliferation, differentiation, EMT/ MET transition, cell signaling, response to infection, induction of pluripotent stem cells and cell metabolism. As discussed in other excellent chapters of this book, the roles of miRNAs in cancer development have been extensively studied. Here in this chapter, we will discuss the signifi cance of miRNAs in regulating cancer cell metabolism. Specifi cally, we will focus on the roles of miRNAs in mediating metabolism of three major energy substrates including glucose, lipid and glutamine metabolism in cancer development.

Original languageEnglish (US)
Title of host publicationMicroRNAs
Subtitle of host publicationKey Regulators of Oncogenesis
PublisherSpringer International Publishing
Pages83-95
Number of pages13
Volume9783319037257
ISBN (Electronic)9783319037257
ISBN (Print)3319037242, 9783319037240
DOIs
StatePublished - Oct 1 2014

Keywords

  • Cancer metabolism
  • Glucose metabolism
  • Glutamine metabolism
  • Lipid metabolism
  • MicroRNA

ASJC Scopus subject areas

  • Medicine(all)

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