Abstract
In 1927, Otto Warburg demonstrated that cancer cells use glucose for growth and division in a manner that is different from normal cells, a phenomenon known nowadays as Warburg Effect. To date, overwhelming evidence indicates that aberration in metabolism plays important roles in cancer progression. More recently, for more than a decade biologists are fascinated by the functions of small RNAs known as microRNAs (miRNAs), which play vital roles in many important biological processes, such as cell proliferation, differentiation, EMT/ MET transition, cell signaling, response to infection, induction of pluripotent stem cells and cell metabolism. As discussed in other excellent chapters of this book, the roles of miRNAs in cancer development have been extensively studied. Here in this chapter, we will discuss the signifi cance of miRNAs in regulating cancer cell metabolism. Specifi cally, we will focus on the roles of miRNAs in mediating metabolism of three major energy substrates including glucose, lipid and glutamine metabolism in cancer development.
Original language | English (US) |
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Title of host publication | MicroRNAs |
Subtitle of host publication | Key Regulators of Oncogenesis |
Publisher | Springer International Publishing |
Pages | 83-95 |
Number of pages | 13 |
Volume | 9783319037257 |
ISBN (Electronic) | 9783319037257 |
ISBN (Print) | 3319037242, 9783319037240 |
DOIs | |
State | Published - Oct 1 2014 |
Keywords
- Cancer metabolism
- Glucose metabolism
- Glutamine metabolism
- Lipid metabolism
- MicroRNA
ASJC Scopus subject areas
- General Medicine