microRNAs: A Safeguard against Turmoil?

Anthony K.L. Leung, Phillip A. Sharp

Research output: Contribution to journalShort surveypeer-review

Abstract

Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.

Original languageEnglish (US)
Pages (from-to)581-585
Number of pages5
JournalCell
Volume130
Issue number4
DOIs
StatePublished - Aug 24 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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