MicroRNA Regulation of Acute Lung Injury and Acute Respiratory Distress Syndrome

Subbiah Rajasekaran, Dhamotharan Pattarayan, P. Rajaguru, P. S. Sudhakar Gandhi, Rajesh K. Thimmulappa

Research output: Contribution to journalReview articlepeer-review

Abstract

The acute respiratory distress syndrome (ARDS), a severe form of acute lung injury (ALI), is a very common condition associated with critically ill patients, which causes substantial morbidity and mortality worldwide. Despite decades of research, effective therapeutic strategies for clinical ALI/ARDS are not available. In recent years, microRNAs (miRNAs), small non-coding molecules have emerged as a major area of biomedical research as they post-transcriptionally regulate gene expression in diverse biological and pathological processes, including ALI/ARDS. In this context, this present review summarizes a large body of evidence implicating miRNAs and their target molecules in ALI/ARDS originating largely from studies using animal and cell culture model systems of ALI/ARDS. We have also focused on the involvement of miRNAs in macrophage polarization, which play a critical role in regulating the pathogenesis of ALI/ARDS. Finally, the possible future directions that might lead to novel therapeutic strategies for the treatment of ALI/ARDS are also reviewed. J. Cell. Physiol. 231: 2097–2106, 2016.

Original languageEnglish (US)
Pages (from-to)2097-2106
Number of pages10
JournalJournal of Cellular Physiology
Volume231
Issue number10
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

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