MicroRNA involvement in esophageal carcinogenesis

Stefan David, Stephen J. Meltzer

Research output: Contribution to journalReview article

Abstract

MicroRNAs (miRs) have recently emerged as a novel class of gene expression regulators. The number of studies documenting an altered miR expression pattern in cancer continues to expand rapidly. Critical information is continuously gained regarding how aberrantly expressed miRs contribute to carcinogenesis. Current studies provide evidence that analyses of miR expression patterns have potential clinical applications toward developing tumor biomarkers to identify the presence and dissemination of esophageal cancer, as well as to assess tumor chemosensitivity or radiosensitivity. The incidence of esophageal cancer is on the rise, and this disease continues to portend a poor prognosis. The current review addresses ways in which altered miR expression contributes to esophageal carcinogenesis, along with how recent discoveries may be applied clinically.

Original languageEnglish (US)
Pages (from-to)612-616
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume11
Issue number6
DOIs
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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