MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma

Naoki Ikenaga, Kenoki Ohuchida, Kazuhiro Mizumoto, Jun Yu, Tadashi Kayashima, Hiroshi Sakai, Hayato Fujita, Kohei Nakata, Masao Tanaka

Research output: Contribution to journalArticle

Abstract

Background: Detection of aberrant microRNA (miR) expression may contribute to diagnosis and prognosis of various cancers. The aim of this study is to evaluate the correlation between miR-203 expression and prognosis of patients with pancreatic adenocarcinoma after curative resection. Methods: A total of 113 formalin-fixed paraffin-embedded tissue samples of pancreatic adenocarcinoma, 20 samples of chronic pancreatitis, and 8 samples of normal pancreas were obtained. We investigated the association of miR-203 expression measured by quantitative reverse-transcription polymerase chain reaction assays with clinicopathological parameters and survival times. Results: miR-203 was overexpressed in pancreatic adenocarcinoma samples compared with chronic pancreatitis (P <0.001) and normal pancreas (P = 0.001) samples. An association between miR-203 expression and clinicopathological factors of pancreatic adenocarcinoma was not observed. On univariate analysis, the high-miR-203 group and the subgroup (20%) of cases with the highest miR-203 overexpression had significantly shorter survival time (P = 0.048 and P = 0.024, respectively). Multivariate analysis revealed that miR-203 expression was an independent predictor of poor prognosis in cases with no residual tumor (relative risk 2.298, P = 0.027). Conclusions: miR-203 expression is a new prognostic marker in pancreatic adenocarcinoma patients.

Original languageEnglish (US)
Pages (from-to)3120-3128
Number of pages9
JournalAnnals of Surgical Oncology
Volume17
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

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MicroRNAs
Adenocarcinoma
Chronic Pancreatitis
Pancreas
Survival
Residual Neoplasm
Paraffin
Formaldehyde
Reverse Transcription
Multivariate Analysis
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Ikenaga, N., Ohuchida, K., Mizumoto, K., Yu, J., Kayashima, T., Sakai, H., ... Tanaka, M. (2010). MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma. Annals of Surgical Oncology, 17(12), 3120-3128. https://doi.org/10.1245/s10434-010-1188-8

MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma. / Ikenaga, Naoki; Ohuchida, Kenoki; Mizumoto, Kazuhiro; Yu, Jun; Kayashima, Tadashi; Sakai, Hiroshi; Fujita, Hayato; Nakata, Kohei; Tanaka, Masao.

In: Annals of Surgical Oncology, Vol. 17, No. 12, 12.2010, p. 3120-3128.

Research output: Contribution to journalArticle

Ikenaga, N, Ohuchida, K, Mizumoto, K, Yu, J, Kayashima, T, Sakai, H, Fujita, H, Nakata, K & Tanaka, M 2010, 'MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma', Annals of Surgical Oncology, vol. 17, no. 12, pp. 3120-3128. https://doi.org/10.1245/s10434-010-1188-8
Ikenaga, Naoki ; Ohuchida, Kenoki ; Mizumoto, Kazuhiro ; Yu, Jun ; Kayashima, Tadashi ; Sakai, Hiroshi ; Fujita, Hayato ; Nakata, Kohei ; Tanaka, Masao. / MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma. In: Annals of Surgical Oncology. 2010 ; Vol. 17, No. 12. pp. 3120-3128.
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AU - Ikenaga, Naoki

AU - Ohuchida, Kenoki

AU - Mizumoto, Kazuhiro

AU - Yu, Jun

AU - Kayashima, Tadashi

AU - Sakai, Hiroshi

AU - Fujita, Hayato

AU - Nakata, Kohei

AU - Tanaka, Masao

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AB - Background: Detection of aberrant microRNA (miR) expression may contribute to diagnosis and prognosis of various cancers. The aim of this study is to evaluate the correlation between miR-203 expression and prognosis of patients with pancreatic adenocarcinoma after curative resection. Methods: A total of 113 formalin-fixed paraffin-embedded tissue samples of pancreatic adenocarcinoma, 20 samples of chronic pancreatitis, and 8 samples of normal pancreas were obtained. We investigated the association of miR-203 expression measured by quantitative reverse-transcription polymerase chain reaction assays with clinicopathological parameters and survival times. Results: miR-203 was overexpressed in pancreatic adenocarcinoma samples compared with chronic pancreatitis (P <0.001) and normal pancreas (P = 0.001) samples. An association between miR-203 expression and clinicopathological factors of pancreatic adenocarcinoma was not observed. On univariate analysis, the high-miR-203 group and the subgroup (20%) of cases with the highest miR-203 overexpression had significantly shorter survival time (P = 0.048 and P = 0.024, respectively). Multivariate analysis revealed that miR-203 expression was an independent predictor of poor prognosis in cases with no residual tumor (relative risk 2.298, P = 0.027). Conclusions: miR-203 expression is a new prognostic marker in pancreatic adenocarcinoma patients.

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