TY - JOUR
T1 - MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma
AU - Ikenaga, Naoki
AU - Ohuchida, Kenoki
AU - Mizumoto, Kazuhiro
AU - Yu, Jun
AU - Kayashima, Tadashi
AU - Sakai, Hiroshi
AU - Fujita, Hayato
AU - Nakata, Kohei
AU - Tanaka, Masao
N1 - Funding Information:
ACKNOWLEDGMENT This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and grants from the Takeda Science Foundation, Pancreas Research Foundation of Japan, and Nakajima Foundation.
PY - 2010/12
Y1 - 2010/12
N2 - Background: Detection of aberrant microRNA (miR) expression may contribute to diagnosis and prognosis of various cancers. The aim of this study is to evaluate the correlation between miR-203 expression and prognosis of patients with pancreatic adenocarcinoma after curative resection. Methods: A total of 113 formalin-fixed paraffin-embedded tissue samples of pancreatic adenocarcinoma, 20 samples of chronic pancreatitis, and 8 samples of normal pancreas were obtained. We investigated the association of miR-203 expression measured by quantitative reverse-transcription polymerase chain reaction assays with clinicopathological parameters and survival times. Results: miR-203 was overexpressed in pancreatic adenocarcinoma samples compared with chronic pancreatitis (P < 0.001) and normal pancreas (P = 0.001) samples. An association between miR-203 expression and clinicopathological factors of pancreatic adenocarcinoma was not observed. On univariate analysis, the high-miR-203 group and the subgroup (20%) of cases with the highest miR-203 overexpression had significantly shorter survival time (P = 0.048 and P = 0.024, respectively). Multivariate analysis revealed that miR-203 expression was an independent predictor of poor prognosis in cases with no residual tumor (relative risk 2.298, P = 0.027). Conclusions: miR-203 expression is a new prognostic marker in pancreatic adenocarcinoma patients.
AB - Background: Detection of aberrant microRNA (miR) expression may contribute to diagnosis and prognosis of various cancers. The aim of this study is to evaluate the correlation between miR-203 expression and prognosis of patients with pancreatic adenocarcinoma after curative resection. Methods: A total of 113 formalin-fixed paraffin-embedded tissue samples of pancreatic adenocarcinoma, 20 samples of chronic pancreatitis, and 8 samples of normal pancreas were obtained. We investigated the association of miR-203 expression measured by quantitative reverse-transcription polymerase chain reaction assays with clinicopathological parameters and survival times. Results: miR-203 was overexpressed in pancreatic adenocarcinoma samples compared with chronic pancreatitis (P < 0.001) and normal pancreas (P = 0.001) samples. An association between miR-203 expression and clinicopathological factors of pancreatic adenocarcinoma was not observed. On univariate analysis, the high-miR-203 group and the subgroup (20%) of cases with the highest miR-203 overexpression had significantly shorter survival time (P = 0.048 and P = 0.024, respectively). Multivariate analysis revealed that miR-203 expression was an independent predictor of poor prognosis in cases with no residual tumor (relative risk 2.298, P = 0.027). Conclusions: miR-203 expression is a new prognostic marker in pancreatic adenocarcinoma patients.
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U2 - 10.1245/s10434-010-1188-8
DO - 10.1245/s10434-010-1188-8
M3 - Article
C2 - 20652642
AN - SCOPUS:78650991127
SN - 1068-9265
VL - 17
SP - 3120
EP - 3128
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 12
ER -