MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells

Meng Jia, Xuewei Wang, Haolin Zhang, Can Ye, Hui Ma, Mingda Yang, Yijing Li, Cailian Cui

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNA-132 (miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain. Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells (NSCs) and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration (MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, specific overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus (DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These findings indicate that miR-132 is involved in opioid addiction, probably by promoting the differentiation of NSCs in the adult DG.

Original languageEnglish (US)
Pages (from-to)486-496
Number of pages11
JournalNeuroscience Bulletin
Volume35
Issue number3
DOIs
StatePublished - Jun 3 2019
Externally publishedYes

Keywords

  • Dentate gyrus
  • Neural stem cell
  • Opioid addiction
  • miR-132

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Fingerprint Dive into the research topics of 'MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells'. Together they form a unique fingerprint.

Cite this