Abstract
MicroRNAs (miRNAs) have been demonstrated to play a pivotal role in the regulation of target gene expression at the post-transcriptional level. In order to better understand the role of miRNA in the immunological regulation of macrophages against Mycobacterium bovis BCG infection, we explored the alteration of immune-related miRNA profile in macrophage RAW264.7 cells in response to BCG infection in this study. Our results demonstrated that miR-142-3p was a potential to negatively regulate the production of pro-inflammatory mediators NF-κB (NF-κB1), TNF-α and IL-6 in the macrophages in part through a mechanism of targeting IRAK-1 gene and post-transcriptionally down-regulating IRAK-1 protein expression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 606-611 |
| Number of pages | 6 |
| Journal | Tuberculosis |
| Volume | 93 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2013 |
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Keywords
- BCG
- IRAK-1
- Macrophage
- microRNA
- Mycobacterium
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases
- Microbiology (medical)
Cite this
MicroR-142-3p down-regulates IRAK-1 in response to Mycobacterium bovis BCG infection in macrophages. / Xu, Guangxian; Zhang, Zhaobo; Wei, Jun; Zhang, Yilin; Zhang, Ying; Guo, Le; Liu, Xiaoming.
In: Tuberculosis, Vol. 93, No. 6, 11.2013, p. 606-611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MicroR-142-3p down-regulates IRAK-1 in response to Mycobacterium bovis BCG infection in macrophages
AU - Xu, Guangxian
AU - Zhang, Zhaobo
AU - Wei, Jun
AU - Zhang, Yilin
AU - Zhang, Ying
AU - Guo, Le
AU - Liu, Xiaoming
PY - 2013/11
Y1 - 2013/11
N2 - MicroRNAs (miRNAs) have been demonstrated to play a pivotal role in the regulation of target gene expression at the post-transcriptional level. In order to better understand the role of miRNA in the immunological regulation of macrophages against Mycobacterium bovis BCG infection, we explored the alteration of immune-related miRNA profile in macrophage RAW264.7 cells in response to BCG infection in this study. Our results demonstrated that miR-142-3p was a potential to negatively regulate the production of pro-inflammatory mediators NF-κB (NF-κB1), TNF-α and IL-6 in the macrophages in part through a mechanism of targeting IRAK-1 gene and post-transcriptionally down-regulating IRAK-1 protein expression.
AB - MicroRNAs (miRNAs) have been demonstrated to play a pivotal role in the regulation of target gene expression at the post-transcriptional level. In order to better understand the role of miRNA in the immunological regulation of macrophages against Mycobacterium bovis BCG infection, we explored the alteration of immune-related miRNA profile in macrophage RAW264.7 cells in response to BCG infection in this study. Our results demonstrated that miR-142-3p was a potential to negatively regulate the production of pro-inflammatory mediators NF-κB (NF-κB1), TNF-α and IL-6 in the macrophages in part through a mechanism of targeting IRAK-1 gene and post-transcriptionally down-regulating IRAK-1 protein expression.
KW - BCG
KW - IRAK-1
KW - Macrophage
KW - microRNA
KW - Mycobacterium
UR - http://www.scopus.com/inward/record.url?scp=84887406577&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887406577&partnerID=8YFLogxK
U2 - 10.1016/j.tube.2013.08.006
DO - 10.1016/j.tube.2013.08.006
M3 - Article
C2 - 24053976
AN - SCOPUS:84887406577
VL - 93
SP - 606
EP - 611
JO - Tuberculosis
JF - Tuberculosis
SN - 1472-9792
IS - 6
ER -