MicroR-142-3p down-regulates IRAK-1 in response to Mycobacterium bovis BCG infection in macrophages

Guangxian Xu, Zhaobo Zhang, Jun Wei, Yilin Zhang, Ying Zhang, Le Guo, Xiaoming Liu

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNAs (miRNAs) have been demonstrated to play a pivotal role in the regulation of target gene expression at the post-transcriptional level. In order to better understand the role of miRNA in the immunological regulation of macrophages against Mycobacterium bovis BCG infection, we explored the alteration of immune-related miRNA profile in macrophage RAW264.7 cells in response to BCG infection in this study. Our results demonstrated that miR-142-3p was a potential to negatively regulate the production of pro-inflammatory mediators NF-κB (NF-κB1), TNF-α and IL-6 in the macrophages in part through a mechanism of targeting IRAK-1 gene and post-transcriptionally down-regulating IRAK-1 protein expression.

Original languageEnglish (US)
Pages (from-to)606-611
Number of pages6
JournalTuberculosis
Volume93
Issue number6
DOIs
StatePublished - Nov 2013

Keywords

  • BCG
  • IRAK-1
  • Macrophage
  • Mycobacterium
  • microRNA

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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