MicroR-142-3p down-regulates IRAK-1 in response to Mycobacterium bovis BCG infection in macrophages

Guangxian Xu, Zhaobo Zhang, Jun Wei, Yilin Zhang, Ying Zhang, Le Guo, Xiaoming Liu

Research output: Contribution to journalArticle

Abstract

MicroRNAs (miRNAs) have been demonstrated to play a pivotal role in the regulation of target gene expression at the post-transcriptional level. In order to better understand the role of miRNA in the immunological regulation of macrophages against Mycobacterium bovis BCG infection, we explored the alteration of immune-related miRNA profile in macrophage RAW264.7 cells in response to BCG infection in this study. Our results demonstrated that miR-142-3p was a potential to negatively regulate the production of pro-inflammatory mediators NF-κB (NF-κB1), TNF-α and IL-6 in the macrophages in part through a mechanism of targeting IRAK-1 gene and post-transcriptionally down-regulating IRAK-1 protein expression.

Original languageEnglish (US)
Pages (from-to)606-611
Number of pages6
JournalTuberculosis
Volume93
Issue number6
DOIs
StatePublished - Nov 2013

Fingerprint

Mycobacterium bovis
MicroRNAs
Down-Regulation
Macrophages
Infection
Gene Expression Regulation
Interleukin-6
Genes
Proteins

Keywords

  • BCG
  • IRAK-1
  • Macrophage
  • microRNA
  • Mycobacterium

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

MicroR-142-3p down-regulates IRAK-1 in response to Mycobacterium bovis BCG infection in macrophages. / Xu, Guangxian; Zhang, Zhaobo; Wei, Jun; Zhang, Yilin; Zhang, Ying; Guo, Le; Liu, Xiaoming.

In: Tuberculosis, Vol. 93, No. 6, 11.2013, p. 606-611.

Research output: Contribution to journalArticle

Xu, Guangxian ; Zhang, Zhaobo ; Wei, Jun ; Zhang, Yilin ; Zhang, Ying ; Guo, Le ; Liu, Xiaoming. / MicroR-142-3p down-regulates IRAK-1 in response to Mycobacterium bovis BCG infection in macrophages. In: Tuberculosis. 2013 ; Vol. 93, No. 6. pp. 606-611.
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AU - Guo, Le

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