Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: A controlled clinical trial

Richard D. Semba, J. Kumwenda, E. Zijlstra, M. O. Ricks, M. Van Lettow, C. Whalen, T. D. Clark, L. Jorgensen, J. Kohler, N. Kumwenda, T. E. Taha, A. D. Harries

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36 Scopus citations


SETTING: Zomba and Blantyre, Malawi, Africa. OBJECTIVES: To determine whether daily micronutrient supplementation reduces the mortality of human immunodeficiency virus (HIV) infected adults with pulmonary tuberculosis (TB). DESIGN: A randomised, controlled clinical trial of micronutrient supplementation for HIV-positive and HIV-negative adults with pulmonary TB. Participants were enrolled at the commencement of chemotherapy for sputum smear-positive pulmonary TB and followed up for 24 months. RESULTS: A total of 829 HIV-positive and 573 HIV-negative adults were enrolled. During follow-up, 328 HIV-positive and 17 HIV-negative participants died. The proportion of HIV-positive participants who died in the micronutrient and placebo groups was 38.7% and 40.4%, respectively (P = 0.49). Micronutrient supplementation did not reduce mortality (hazard ratio [HR] 0.93, 95%CI 0.75-1.15) among HIV-positive adults. CONCLUSIONS: Micronutrient supplementation at the doses used in this study does not reduce mortality in HIV-positive adults with pulmonary TB in Malawi.

Original languageEnglish (US)
Pages (from-to)854-859
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number8
StatePublished - Aug 2007


  • Africa
  • HIV
  • Malnutrition
  • Micronutrient
  • Mortality
  • TB

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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