Micronutrient malnutrition and wasting in adults with pulmonary tuberculosis with and without HIV co-infection in Malawi

Monique van Lettow, Anthony D. Harries, Johnny J. Kumwenda, Ed E. Zijlstra, Tamara D. Clark, Taha E Taha, Richard David Semba

Research output: Contribution to journalArticle

Abstract

Background: Wasting and micronutrient malnutrition have not been well characterized in adults with pulmonary tuberculosis. We hypothesized that micronutrient malnutrition is associated with wasting and higher plasma human immunodeficiency virus (HIV) load in adults with pulmonary tuberculosis. Methods: In a cross-sectional study involving 579 HIV-positive and 222 HIV-negative adults with pulmonary tuberculosis in Zomba, Malawi, anthropometry, plasma HIV load and plasma micronutrient concentrations (retinol, α-tocopherol, carotenoids, zinc, and selenium) were measured. The risk of micronutrient deficiencies was examined at different severity levels of wasting. Results: Body mass index (BMI), plasma retinol, carotenoid and selenium concentrations significantly decreased by increasing tertile of plasma HIV load. There were no significant differences in plasma micronutrient concentrations between HIV-negative individuals and HIV-positive individuals who were in the lowest tertile of plasma HIV load. Plasma vitamin A concentrations

Original languageEnglish (US)
JournalBMC Infectious Diseases
Volume4
DOIs
StatePublished - Dec 21 2004

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Malawi
Micronutrients
Virus Diseases
Coinfection
Pulmonary Tuberculosis
Malnutrition
HIV
Vitamin A
Carotenoids
Selenium
Anthropometry
Tocopherols
Zinc
Body Mass Index
Cross-Sectional Studies

ASJC Scopus subject areas

  • Infectious Diseases

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Micronutrient malnutrition and wasting in adults with pulmonary tuberculosis with and without HIV co-infection in Malawi. / van Lettow, Monique; Harries, Anthony D.; Kumwenda, Johnny J.; Zijlstra, Ed E.; Clark, Tamara D.; Taha, Taha E; Semba, Richard David.

In: BMC Infectious Diseases, Vol. 4, 21.12.2004.

Research output: Contribution to journalArticle

van Lettow, Monique ; Harries, Anthony D. ; Kumwenda, Johnny J. ; Zijlstra, Ed E. ; Clark, Tamara D. ; Taha, Taha E ; Semba, Richard David. / Micronutrient malnutrition and wasting in adults with pulmonary tuberculosis with and without HIV co-infection in Malawi. In: BMC Infectious Diseases. 2004 ; Vol. 4.
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AU - Harries, Anthony D.

AU - Kumwenda, Johnny J.

AU - Zijlstra, Ed E.

AU - Clark, Tamara D.

AU - Taha, Taha E

AU - Semba, Richard David

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