TY - JOUR
T1 - Micronutrient Deficiencies in Systemic Sclerosis
T2 - A Scoping Review
AU - Nguyen, Audrey D.
AU - McMahan, Zsuzsanna H.
AU - Volkmann, Elizabeth R.
N1 - Funding Information:
Elizabeth R Volkmann reports grants and personal fees from Boehringer Ingelheim, and grants from Kadmon, Horizon, Corbus, and Forbius, outside the submitted work. The authors report no other potential conflicts of interest or competing interests in this work. The abstract of this paper with interim findings was published in the “Abstract Book” of the Annual European Congress of Rheumatology EULAR 2021, an official supplement to Annals of the Rheumatic Diseases (http://dx.doi.org/10.1136/annrheumdis-2021-eular.1420)
Funding Information:
This work was supported by grants from NIH/NHLBI: K23 HL150237 to ERV; NIH/NIAMS K23 AR071473, Scleroderma Research Foundation, Rheumatology Research Foundation K23 Supplement, and Jerome L Greene Foundation to ZM. The study sponsors had no role in the study design, data collection, data synthesis, and interpretation of data, nor in the writing of the report and in the decision to submit the paper for publications. None of the authors have been paid to write this article by a pharmaceutical company or other agency.
Publisher Copyright:
© 2022 Nguyen et al.
PY - 2022/12
Y1 - 2022/12
N2 - Purpose: The primary aim is to identify the micronutrient deficiencies commonly reported in SSc. The exploratory aim is to evaluate associations between micronutrient deficiencies and SSc clinical manifestations. Patient and Methods: We conducted a scoping review of all published reports on SSc and nutrition in PubMed from its inception to August 2020. Clinical trials, observational studies, meta-analyses, and case series (with ≥20 cases) containing data on nutritional deficiency and SSc were included. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for reporting our findings. Two reviewers (ADN and ERV) studied the titles and abstracts of all search results with pre-specified inclusion and exclusion criteria. Results: Among 790 retrieved publications, 35 full-length articles and 3 abstracts met the inclusion/exclusion criteria. Included studies took place across multiple geographic locations and included patients with both diffuse and limited cutaneous SSc. Vitamin D deficiency was the most commonly reported deficiency described in SSc, followed by vitamin B12, vitamin B9, selenium, zinc, and iron. In addition, some small studies found deficiencies in vitamins B1, B6, C, E, and A. While some studies reported associations between specific micronutrient deficiencies and SSc disease features (eg, interstitial lung disease was commonly associated with vitamin D deficiency and elevated homocysteine [Hcy]), the evidence to support these associations was not robust. Conclusion: Micronutrient deficiencies are common in SSc and are associated with specific SSc features. Routine screening for micronutrient deficiencies may lead to early detection of malnutrition. Future studies are needed to understand how interventions to replete micronutrient deficiencies affect patient outcomes in SSc.
AB - Purpose: The primary aim is to identify the micronutrient deficiencies commonly reported in SSc. The exploratory aim is to evaluate associations between micronutrient deficiencies and SSc clinical manifestations. Patient and Methods: We conducted a scoping review of all published reports on SSc and nutrition in PubMed from its inception to August 2020. Clinical trials, observational studies, meta-analyses, and case series (with ≥20 cases) containing data on nutritional deficiency and SSc were included. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for reporting our findings. Two reviewers (ADN and ERV) studied the titles and abstracts of all search results with pre-specified inclusion and exclusion criteria. Results: Among 790 retrieved publications, 35 full-length articles and 3 abstracts met the inclusion/exclusion criteria. Included studies took place across multiple geographic locations and included patients with both diffuse and limited cutaneous SSc. Vitamin D deficiency was the most commonly reported deficiency described in SSc, followed by vitamin B12, vitamin B9, selenium, zinc, and iron. In addition, some small studies found deficiencies in vitamins B1, B6, C, E, and A. While some studies reported associations between specific micronutrient deficiencies and SSc disease features (eg, interstitial lung disease was commonly associated with vitamin D deficiency and elevated homocysteine [Hcy]), the evidence to support these associations was not robust. Conclusion: Micronutrient deficiencies are common in SSc and are associated with specific SSc features. Routine screening for micronutrient deficiencies may lead to early detection of malnutrition. Future studies are needed to understand how interventions to replete micronutrient deficiencies affect patient outcomes in SSc.
KW - malnutrition
KW - micronutrient deficiency
KW - nutritional deficiency
KW - systemic sclerosis
KW - vitamin deficiency
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U2 - 10.2147/OARRR.S354736
DO - 10.2147/OARRR.S354736
M3 - Review article
C2 - 36571105
AN - SCOPUS:85146848295
SN - 1179-156X
VL - 14
SP - 309
EP - 327
JO - Open Access Rheumatology: Research and Reviews
JF - Open Access Rheumatology: Research and Reviews
ER -