Micrometastases in bone marrow of patients with suspected pancreatic and ampullary cancer

N. T. Van Heek, M. Tascilar, J. L. Van Beekveld, P. Drillenburg, G. J A Offerhaus, D. J. Gouma

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: This prospective study aimed to evaluate the detection of micrometastases in bone marrow of patients with suspected pancreatic and ampullary cancer and to determine their predictive value on overall survival. Methods: Between December 1997 and December 1998, 35 patients (19 male, 42-77 years) with suspected pancreatic and ampullary cancer underwent diagnostic laparoscopy as a final staging procedure before exploration. Bone marrow was aspirated from the iliac crest at the beginning of laparoscopy. Mononuclear cells were isolated and stained using the specific monoclonal antibody CAM 5.2. Results: Cytokeratin-positive cells were detected in 12/35 (34%) of all patients. In the 31 patients with a final diagnosis of carcinoma, a positive staining was found in 10/31 (32%) of the bone marrow aspirates. After a median follow-up of 17 months (2-24), 15/31 (48%) patients had died: 7/10 (70%) with and 8/21 (38%) without micrometastases (*P

Original languageEnglish (US)
Pages (from-to)740-745
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume27
Issue number8
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Bone marrow
  • Immunocytochemistry
  • Pancreatic neoplasms
  • Survival rate

ASJC Scopus subject areas

  • Oncology
  • Surgery

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