TY - JOUR
T1 - Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage
AU - Zhang, Zhen
AU - Zhang, Ze
AU - Lu, Hong
AU - Yang, Qingwu
AU - Wu, He
AU - Wang, Jian
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH and highlights the potential targets for ICH treatment.
AB - Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH and highlights the potential targets for ICH treatment.
KW - Inflammatory mediators
KW - Intracerebral hemorrhage
KW - Microglia
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U2 - 10.1007/s12035-016-9785-6
DO - 10.1007/s12035-016-9785-6
M3 - Review article
C2 - 26894396
AN - SCOPUS:84958739618
SN - 0893-7648
VL - 54
SP - 1874
EP - 1886
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 3
ER -