Microglial nodule encephalitis: Limited CNS infection despite disseminated systemic cryptococcosis

M. Edelman, M. C. Birkenhauer, J. J. Steinberg, D. W. Dickson, Arturo Casadevall, S. C. Lee

Research output: Contribution to journalArticle

Abstract

A 28-year-old patient with AIDS was found at autopsy to have disseminated cryptococcal infection involving the lungs, spleen, lymph nodes, kidneys, gastrointestinal tract, thyroid, bone marrow, and liver. Despite widespread organ dissemination the patient did not have clinical or pathological evidence of meningitis. Microscopic examination of the brain showed cryptococci limited to the brainstem and basal ganglia; microglial nodules with multinucleate giant cells, a histological hallmark of HIV-1 encephalitis, were shown to contain Cryptococcus neoformans. This feature may suggest a form of synergism between HIV-1 and Cryptococcus neoformans. This case demonstrates an unusual form of cryptococcal neurotropism with limited CNS involvement.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalClinical Neuropathology
Volume15
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Cryptococcosis
Cryptococcus neoformans
Encephalitis
HIV-1
Cryptococcus
Giant Cells
Infection
Basal Ganglia
Meningitis
Brain Stem
Gastrointestinal Tract
Autopsy
Thyroid Gland
Acquired Immunodeficiency Syndrome
Spleen
Lymph Nodes
Bone Marrow
Kidney
Lung
Liver

Keywords

  • AIDS
  • Cryptococcus neoformans
  • HIV-1
  • Invasive mycosis
  • Meningitis
  • Polysaccharide

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Edelman, M., Birkenhauer, M. C., Steinberg, J. J., Dickson, D. W., Casadevall, A., & Lee, S. C. (1996). Microglial nodule encephalitis: Limited CNS infection despite disseminated systemic cryptococcosis. Clinical Neuropathology, 15(1), 30-33.

Microglial nodule encephalitis : Limited CNS infection despite disseminated systemic cryptococcosis. / Edelman, M.; Birkenhauer, M. C.; Steinberg, J. J.; Dickson, D. W.; Casadevall, Arturo; Lee, S. C.

In: Clinical Neuropathology, Vol. 15, No. 1, 1996, p. 30-33.

Research output: Contribution to journalArticle

Edelman, M, Birkenhauer, MC, Steinberg, JJ, Dickson, DW, Casadevall, A & Lee, SC 1996, 'Microglial nodule encephalitis: Limited CNS infection despite disseminated systemic cryptococcosis', Clinical Neuropathology, vol. 15, no. 1, pp. 30-33.
Edelman, M. ; Birkenhauer, M. C. ; Steinberg, J. J. ; Dickson, D. W. ; Casadevall, Arturo ; Lee, S. C. / Microglial nodule encephalitis : Limited CNS infection despite disseminated systemic cryptococcosis. In: Clinical Neuropathology. 1996 ; Vol. 15, No. 1. pp. 30-33.
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