Microglial activation in human diabetic retinopathy

Hui Yang Zeng, William Richard Green, Mark O M Tso

Research output: Contribution to journalArticle

Abstract

Objective: To investigate microglial activation in human diabetic retinopathy. Methods: Paraffin sections from 21 eyes of 13 patients with diabetic background, preproliferative, or proliferative retinopathies and 10 normal eyes of 9 individuals were studied with immunolabeling of microglia with antibodies against HLA-DR antigen, CD45, or CD68. Results: In the healthy human eyes, ramified microglial cells were scattered in the inner retinal layers. In eyes with diabetic retinopathy, the microglia were markedly increased in number and were hypertrophic at different stages of the disease. These cells clustered around the retinal vasculature, especially the dilated veins, microaneurysms, intraretinal hemorrhages, cotton-wool spots, optic nerve, and retinal and vitreal neovascularization. In some retinas with cystoid macular edema, microglia infiltrated the outer retina and subretinal space. Cells in the epiretinal membrane were also labeled with microglial markers. Conclusions: Microglia were activated at different stages of human diabetic retinopathy and optic neuropathy. Microglial perivasculitis was a prominent feature of the disease process. Clinical Relevance: Activated microglia and microglial perivasculitis may play a role in vasculopathy and neuropathy in diabetic retinopathy.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalArchives of Ophthalmology
Volume126
Issue number2
DOIs
StatePublished - Feb 2008

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Microglia
Diabetic Retinopathy
Retina
Retinal Neovascularization
Epiretinal Membrane
Optic Nerve Diseases
Macular Edema
Diabetic Neuropathies
Wool
HLA-DR Antigens
Optic Nerve
Paraffin
Veins
Hemorrhage
Antibodies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Microglial activation in human diabetic retinopathy. / Zeng, Hui Yang; Green, William Richard; Tso, Mark O M.

In: Archives of Ophthalmology, Vol. 126, No. 2, 02.2008, p. 227-232.

Research output: Contribution to journalArticle

Zeng, Hui Yang ; Green, William Richard ; Tso, Mark O M. / Microglial activation in human diabetic retinopathy. In: Archives of Ophthalmology. 2008 ; Vol. 126, No. 2. pp. 227-232.
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