@article{3c6245f6f76140a8af40c7f0156e70f5,
title = "Microglia and astrocyte dysfunction in parkinson's disease",
abstract = "While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.",
keywords = "Astrocyte, Glia, Microglia, Neurodegeneration, Neurodegenerative disease, Neuroinflammation, Parkinson's disease",
author = "Kam, {Tae In} and Hinkle, {Jared T.} and Dawson, {Ted M.} and Dawson, {Valina L.}",
note = "Funding Information: This work was supported by NIH/NINDS grant NS38377 and the JPB Foundation. J.T.H. receives tuition and stipend support through the Medical Scientist Training Program at the Johns Hopkins School of Medicine (NIH/NIGMS T32GM007309) and through the National Institute on Aging (F30AG067643). T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. The authors thank I-Hsun Wu for assistance with the illustrations. T.M.D. and V.L.D. are founders of and hold shares of stock options and equity in Neuraly, Inc. and they are inventors of some of the technology discussed in this article, which Neuraly, Inc. has licensed from Johns Hopkins University. T.M.D. and V.L.D. are founders of, and are interim Chief Scientific Officer and Chief Executive Officer of, respectively, hold equity in, serve on the Board of Directors of, and are compensated for their roles as consultants to Valted Seq Inc. T.M.D. and V.L.D. are founders of Valted, LLC and hold an ownership equity interest in the company and the value of patents owned by Valted, LLC could be affected by this article. T.M.D. and V.L.D. are consultants to Inhibikase Therapeutics and own stock options in the company. T.M.D. is a paid consultant to Sun Pharmaceutical Industries Ltd. Funding Information: This work was supported by NIH/NINDS grant NS38377 and the JPB Foundation . J.T.H. receives tuition and stipend support through the Medical Scientist Training Program at the Johns Hopkins School of Medicine (NIH/NIGMS T32GM007309 ) and through the National Institute on Aging ( F30AG067643 ). T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. The authors thank I-Hsun Wu for assistance with the illustrations. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = oct,
doi = "10.1016/j.nbd.2020.105028",
language = "English (US)",
volume = "144",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press Inc.",
}