Microglia and astrocyte dysfunction in parkinson's disease

Research output: Contribution to journalReview articlepeer-review

Abstract

While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.

Original languageEnglish (US)
Article number105028
JournalNeurobiology of Disease
Volume144
DOIs
StatePublished - Oct 2020

Keywords

  • Astrocyte
  • Glia
  • Microglia
  • Neurodegeneration
  • Neurodegenerative disease
  • Neuroinflammation
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology

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