Microglia and astrocyte dysfunction in parkinson's disease

Tae In Kam; Jared T. Hinkle; Ted M. Dawson; Valina L. Dawson

doi:10.1016/j.nbd.2020.105028

Microglia and astrocyte dysfunction in parkinson's disease

Tae In Kam, Jared T. Hinkle, Ted M. Dawson, Valina L. Dawson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.

Original language	English (US)
Article number	105028
Journal	Neurobiology of Disease
Volume	144
DOIs	https://doi.org/10.1016/j.nbd.2020.105028
State	Published - Oct 2020

Keywords

Astrocyte
Glia
Microglia
Neurodegeneration
Neurodegenerative disease
Neuroinflammation
Parkinson's disease

ASJC Scopus subject areas

Neurology

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title = "Microglia and astrocyte dysfunction in parkinson's disease",

abstract = "While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.",

keywords = "Astrocyte, Glia, Microglia, Neurodegeneration, Neurodegenerative disease, Neuroinflammation, Parkinson's disease",

author = "Kam, {Tae In} and Hinkle, {Jared T.} and Dawson, {Ted M.} and Dawson, {Valina L.}",

note = "Funding Information: This work was supported by NIH/NINDS grant NS38377 and the JPB Foundation . J.T.H. receives tuition and stipend support through the Medical Scientist Training Program at the Johns Hopkins School of Medicine (NIH/NIGMS T32GM007309 ) and through the National Institute on Aging ( F30AG067643 ). T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. The authors thank I-Hsun Wu for assistance with the illustrations. ",

year = "2020",

month = oct,

doi = "10.1016/j.nbd.2020.105028",

language = "English (US)",

volume = "144",

journal = "Neurobiology of Disease",

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publisher = "Academic Press Inc.",

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T1 - Microglia and astrocyte dysfunction in parkinson's disease

AU - Kam, Tae In

AU - Hinkle, Jared T.

AU - Dawson, Ted M.

AU - Dawson, Valina L.

N1 - Funding Information: This work was supported by NIH/NINDS grant NS38377 and the JPB Foundation . J.T.H. receives tuition and stipend support through the Medical Scientist Training Program at the Johns Hopkins School of Medicine (NIH/NIGMS T32GM007309 ) and through the National Institute on Aging ( F30AG067643 ). T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. The authors thank I-Hsun Wu for assistance with the illustrations.

PY - 2020/10

Y1 - 2020/10

N2 - While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.

AB - While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.

KW - Astrocyte

KW - Glia

KW - Microglia

KW - Neurodegeneration

KW - Neurodegenerative disease

KW - Neuroinflammation

KW - Parkinson's disease

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