Microfluidics based phantoms of superficial vascular network

Long Luu, Patrick A. Roman, Scott A. Mathews, Jessica C. Ramella-Roman

Research output: Contribution to journalArticlepeer-review

Abstract

Several new bio-photonic techniques aim to measure flow in the human vasculature non-destructively. Some of these tools, such as laser speckle imaging or Doppler optical coherence tomography, are now reaching the clinical stage. Therefore appropriate calibration and validation techniques dedicated to these particular measurements are therefore of paramount importance. In this paper we introduce a fast prototyping technique based on laser micromachining for the fabrication of dynamic flow phantoms. Micro-channels smaller than 20 μm in width can be formed in a variety of materials such as epoxies, plastics, and household tape. Vasculature geometries can be easily and quickly modified to accommodate a particular experimental scenario.

Original languageEnglish (US)
Pages (from-to)1350-1364
Number of pages15
JournalBiomedical Optics Express
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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