Microfluidic approaches for gene delivery and gene therapy

Jungkyu Kim, Inseong Hwang, Derek Britain, Taek Dong Chung, Yu Sun, Deok Ho Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent advances in microfluidics have created new and exciting prospects for gene delivery and therapy. The micro-scaled environment within microfluidic systems enables precise control and optimization of multiple processes and techniques used in gene transfection and the production of gene and drug transporters. Traditional non-viral gene transfection methods, such as electroporation, microinjection and optical gene transfection, are improved from the use of innovative microfluidic systems. Additionally, microfluidic systems have also made the production of many viral and non-viral vectors controlled, automated, and reproducible. In summary, the development and application of microfluidic systems are producing increased efficiency in gene delivery and promise improved gene therapy results.

Original languageEnglish (US)
Pages (from-to)3941-3948
Number of pages8
JournalLab on a Chip
Volume11
Issue number23
DOIs
StatePublished - Dec 7 2011
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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