Microfabrication and self-assembly of 3D microboxes for biomedical applications

Timothy Leong; Hongke Ye; Emma Call; Barjor Gimi; Zaver Bhujwalla; David H. Gracias

Microfabrication and self-assembly of 3D microboxes for biomedical applications

Timothy Leong, Hongke Ye, Emma Call, Barjor Gimi, Zaver Bhujwalla, David H. Gracias

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper reports a novel method for fabricating three dimensional (3D) metallic micropatterned boxes by self-assembly of two dimensional (2D) precursors. A 3D micropatterned device has several advantages over its two dimensional (2D) counterpart - a larger surface area to volume ratio, thereby maximizing interactions with the surrounding medium and providing space to mount different electromechanical modules, and a finite volume allowing encapsulation of functional elements. The microboxes can be constructed in different sizes with perforations on either one or on all faces. We demonstrate encapsulation of gels and polymers within the boxes, and release of chemicals by heating. We envision the use of these boxes in cellular encapsulation and remote release of drugs and biological media in-vitro and in-vivo.

Original language	English (US)
Title of host publication	19th IEEE International Conference on Micro Electro Mechanical Systems
Pages	502-505
Number of pages	4
State	Published - 2006
Event	19th IEEE International Conference on Micro Electro Mechanical Systems - Istanbul, Turkey Duration: Jan 22 2006 → Jan 26 2006

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2006
ISSN (Print)	1084-6999

Other

Other	19th IEEE International Conference on Micro Electro Mechanical Systems
Country/Territory	Turkey
City	Istanbul
Period	1/22/06 → 1/26/06

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Cite this

Leong, T., Ye, H., Call, E., Gimi, B., Bhujwalla, Z., & Gracias, D. H. (2006). Microfabrication and self-assembly of 3D microboxes for biomedical applications. In 19th IEEE International Conference on Micro Electro Mechanical Systems (pp. 502-505). Article 1627846 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2006).

Microfabrication and self-assembly of 3D microboxes for biomedical applications. / Leong, Timothy; Ye, Hongke; Call, Emma et al.
19th IEEE International Conference on Micro Electro Mechanical Systems. 2006. p. 502-505 1627846 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2006).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Leong, T, Ye, H, Call, E, Gimi, B, Bhujwalla, Z & Gracias, DH 2006, Microfabrication and self-assembly of 3D microboxes for biomedical applications. in 19th IEEE International Conference on Micro Electro Mechanical Systems., 1627846, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2006, pp. 502-505, 19th IEEE International Conference on Micro Electro Mechanical Systems, Istanbul, Turkey, 1/22/06.

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abstract = "This paper reports a novel method for fabricating three dimensional (3D) metallic micropatterned boxes by self-assembly of two dimensional (2D) precursors. A 3D micropatterned device has several advantages over its two dimensional (2D) counterpart - a larger surface area to volume ratio, thereby maximizing interactions with the surrounding medium and providing space to mount different electromechanical modules, and a finite volume allowing encapsulation of functional elements. The microboxes can be constructed in different sizes with perforations on either one or on all faces. We demonstrate encapsulation of gels and polymers within the boxes, and release of chemicals by heating. We envision the use of these boxes in cellular encapsulation and remote release of drugs and biological media in-vitro and in-vivo.",

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AU - Ye, Hongke

AU - Call, Emma

AU - Gimi, Barjor

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AU - Gracias, David H.

PY - 2006

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N2 - This paper reports a novel method for fabricating three dimensional (3D) metallic micropatterned boxes by self-assembly of two dimensional (2D) precursors. A 3D micropatterned device has several advantages over its two dimensional (2D) counterpart - a larger surface area to volume ratio, thereby maximizing interactions with the surrounding medium and providing space to mount different electromechanical modules, and a finite volume allowing encapsulation of functional elements. The microboxes can be constructed in different sizes with perforations on either one or on all faces. We demonstrate encapsulation of gels and polymers within the boxes, and release of chemicals by heating. We envision the use of these boxes in cellular encapsulation and remote release of drugs and biological media in-vitro and in-vivo.

AB - This paper reports a novel method for fabricating three dimensional (3D) metallic micropatterned boxes by self-assembly of two dimensional (2D) precursors. A 3D micropatterned device has several advantages over its two dimensional (2D) counterpart - a larger surface area to volume ratio, thereby maximizing interactions with the surrounding medium and providing space to mount different electromechanical modules, and a finite volume allowing encapsulation of functional elements. The microboxes can be constructed in different sizes with perforations on either one or on all faces. We demonstrate encapsulation of gels and polymers within the boxes, and release of chemicals by heating. We envision the use of these boxes in cellular encapsulation and remote release of drugs and biological media in-vitro and in-vivo.

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Microfabrication and self-assembly of 3D microboxes for biomedical applications

Abstract

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ASJC Scopus subject areas

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