Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling

Darius J. Karimipour, Sewon Kang, Timothy M. Johnson, Jeffrey S. Orringer, Ted Hamilton, Craig Hammerberg, John J. Voorhees, Gary Fisher

Research output: Contribution to journalArticle

Abstract

Background: Microdermabrasion is a popular method of superficial skin resurfacing with effects on dermal remodeling. Objective: The purpose of this study was to evaluate the relative importance of the two components of microdermabrasion, negative pressure and abrasion, in stimulating expression of key genes involved in dermal remodeling. Methods: Ten subjects were treated with a microdermabrasion machine using focal crystal abrasion and negative pressure or negative pressure alone for 3 seconds. Serial biochemical analyses were performed. Reverse transcriptase real-time polymerase chain reaction assays were used to evaluate changes in transcription factor activator protein-1, primary cytokines (interleukin 1β, tumor necrosis factor-α), and matrix metalloproteinases (MMP-1, MMP-3, MMP-9). Results: Significant increases in gene expression of the c-Jun component of activator protein-1, interleukin 1β, tumor necrosis factor-α, MMP-1, MMP-3, and MMP-9 were found with crystal abrasion combined with negative pressure. Negative pressure alone resulted in increased gene expression of MMP-1 and MMP-3 but of a quantitatively reduced magnitude when compared with negative pressure with crystal abrasion. Limitations: It is unclear that molecular changes seen with these treatments can result in clinical effect. Conclusion: The abrasive component of microdermabrasion is necessary for stimulating expression of key genes involved in dermal remodeling.

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume54
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

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Aluminum Oxide
Matrix Metalloproteinases
Skin
Pressure
Gene Expression
Transcription Factor AP-1
Interleukin-1
Tumor Necrosis Factor-alpha
Matrix Metalloproteinase 1
Reverse Transcriptase Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction
Transcription Factors
Cytokines

ASJC Scopus subject areas

  • Dermatology

Cite this

Microdermabrasion with and without aluminum oxide crystal abrasion : A comparative molecular analysis of dermal remodeling. / Karimipour, Darius J.; Kang, Sewon; Johnson, Timothy M.; Orringer, Jeffrey S.; Hamilton, Ted; Hammerberg, Craig; Voorhees, John J.; Fisher, Gary.

In: Journal of the American Academy of Dermatology, Vol. 54, No. 3, 03.2006, p. 405-410.

Research output: Contribution to journalArticle

Karimipour, Darius J. ; Kang, Sewon ; Johnson, Timothy M. ; Orringer, Jeffrey S. ; Hamilton, Ted ; Hammerberg, Craig ; Voorhees, John J. ; Fisher, Gary. / Microdermabrasion with and without aluminum oxide crystal abrasion : A comparative molecular analysis of dermal remodeling. In: Journal of the American Academy of Dermatology. 2006 ; Vol. 54, No. 3. pp. 405-410.
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