TY - JOUR
T1 - Microdermabrasion with and without aluminum oxide crystal abrasion
T2 - A comparative molecular analysis of dermal remodeling
AU - Karimipour, Darius J.
AU - Kang, Sewon
AU - Johnson, Timothy M.
AU - Orringer, Jeffrey S.
AU - Hamilton, Ted
AU - Hammerberg, Craig
AU - Voorhees, John J.
AU - Fisher, Gary
N1 - Funding Information:
Funding sources: Research for this article supported by the Skin Surgical Research Fund at the University of Michigan, Bella Products, and a Dermatology Foundation Clinical Career Development Award (to D. J. K.).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/3
Y1 - 2006/3
N2 - Background: Microdermabrasion is a popular method of superficial skin resurfacing with effects on dermal remodeling. Objective: The purpose of this study was to evaluate the relative importance of the two components of microdermabrasion, negative pressure and abrasion, in stimulating expression of key genes involved in dermal remodeling. Methods: Ten subjects were treated with a microdermabrasion machine using focal crystal abrasion and negative pressure or negative pressure alone for 3 seconds. Serial biochemical analyses were performed. Reverse transcriptase real-time polymerase chain reaction assays were used to evaluate changes in transcription factor activator protein-1, primary cytokines (interleukin 1β, tumor necrosis factor-α), and matrix metalloproteinases (MMP-1, MMP-3, MMP-9). Results: Significant increases in gene expression of the c-Jun component of activator protein-1, interleukin 1β, tumor necrosis factor-α, MMP-1, MMP-3, and MMP-9 were found with crystal abrasion combined with negative pressure. Negative pressure alone resulted in increased gene expression of MMP-1 and MMP-3 but of a quantitatively reduced magnitude when compared with negative pressure with crystal abrasion. Limitations: It is unclear that molecular changes seen with these treatments can result in clinical effect. Conclusion: The abrasive component of microdermabrasion is necessary for stimulating expression of key genes involved in dermal remodeling.
AB - Background: Microdermabrasion is a popular method of superficial skin resurfacing with effects on dermal remodeling. Objective: The purpose of this study was to evaluate the relative importance of the two components of microdermabrasion, negative pressure and abrasion, in stimulating expression of key genes involved in dermal remodeling. Methods: Ten subjects were treated with a microdermabrasion machine using focal crystal abrasion and negative pressure or negative pressure alone for 3 seconds. Serial biochemical analyses were performed. Reverse transcriptase real-time polymerase chain reaction assays were used to evaluate changes in transcription factor activator protein-1, primary cytokines (interleukin 1β, tumor necrosis factor-α), and matrix metalloproteinases (MMP-1, MMP-3, MMP-9). Results: Significant increases in gene expression of the c-Jun component of activator protein-1, interleukin 1β, tumor necrosis factor-α, MMP-1, MMP-3, and MMP-9 were found with crystal abrasion combined with negative pressure. Negative pressure alone resulted in increased gene expression of MMP-1 and MMP-3 but of a quantitatively reduced magnitude when compared with negative pressure with crystal abrasion. Limitations: It is unclear that molecular changes seen with these treatments can result in clinical effect. Conclusion: The abrasive component of microdermabrasion is necessary for stimulating expression of key genes involved in dermal remodeling.
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U2 - 10.1016/j.jaad.2005.11.1084
DO - 10.1016/j.jaad.2005.11.1084
M3 - Article
C2 - 16488289
AN - SCOPUS:32644444222
SN - 0190-9622
VL - 54
SP - 405
EP - 410
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -