Microdermabrasion: a molecular analysis following a single treatment.

Darius J. Karimipour, Sewon Kang, Timothy M. Johnson, Jeffrey S. Orringer, Ted Hamilton, Craig Hammerberg, John J. Voorhees, Gary Fisher

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Microdermabrasion is a popular method of superficial skin resurfacing. It is unclear if dermal remodeling actually occurs. OBJECTIVE: To rigorously investigate the molecular alterations observed following a single microdermabrasion treatment. METHODS: Forty-nine subjects received a single microdermabrasion treatment to buttock skin. Serial in vivo biochemical and immunohistological analyses were performed. Reverse transcriptase real-time polymerase chain reaction and immunohistochemistry assays were used to evaluate changes in transcription factors (AP-1, NF-kappaB), primary cytokines (interleukin-1beta, tumor necrosis factor-alpha), matrix metalloproteinases (MMP-1, MMP-3, MMP-9), barrier repair enzymes (acetyl-coenzyme A carboxylase, 3-hydroxy-3-methylglutaryl coenzyme A reductase), and type I procollagen. Results Elevation of transcription factors, primary cytokines, and matrix metalloproteinases occurs rapidly after a single microdermabrasion treatment. Two of 11 subjects also demonstrated increased type I procollagen messenger RNA and protein levels 14 days after treatment. No alteration in stratum corneum thickness was detected. CONCLUSION: Microdermabrasion activates a dermal remodeling/wound healing cascade with minimal epidermal disruption. Evidence now exists to further study manipulation of variables such as number and timing of microdermabrasion sessions.

Original languageEnglish (US)
Pages (from-to)215-223
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume52
Issue number2
StatePublished - Feb 2005
Externally publishedYes

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Matrix Metalloproteinases
Skin
Collagen Type I
Enzymes and Coenzymes
Cytokines
Acetyl-CoA Carboxylase
Matrix Metalloproteinase 1
Buttocks
NF-kappa B
Transcription Factor AP-1
Therapeutics
Reverse Transcriptase Polymerase Chain Reaction
Interleukin-1beta
Wound Healing
Cornea
Real-Time Polymerase Chain Reaction
Oxidoreductases
Transcription Factors
Tumor Necrosis Factor-alpha
Immunohistochemistry

ASJC Scopus subject areas

  • Dermatology

Cite this

Karimipour, D. J., Kang, S., Johnson, T. M., Orringer, J. S., Hamilton, T., Hammerberg, C., ... Fisher, G. (2005). Microdermabrasion: a molecular analysis following a single treatment. Journal of the American Academy of Dermatology, 52(2), 215-223.

Microdermabrasion : a molecular analysis following a single treatment. / Karimipour, Darius J.; Kang, Sewon; Johnson, Timothy M.; Orringer, Jeffrey S.; Hamilton, Ted; Hammerberg, Craig; Voorhees, John J.; Fisher, Gary.

In: Journal of the American Academy of Dermatology, Vol. 52, No. 2, 02.2005, p. 215-223.

Research output: Contribution to journalArticle

Karimipour, DJ, Kang, S, Johnson, TM, Orringer, JS, Hamilton, T, Hammerberg, C, Voorhees, JJ & Fisher, G 2005, 'Microdermabrasion: a molecular analysis following a single treatment.', Journal of the American Academy of Dermatology, vol. 52, no. 2, pp. 215-223.
Karimipour DJ, Kang S, Johnson TM, Orringer JS, Hamilton T, Hammerberg C et al. Microdermabrasion: a molecular analysis following a single treatment. Journal of the American Academy of Dermatology. 2005 Feb;52(2):215-223.
Karimipour, Darius J. ; Kang, Sewon ; Johnson, Timothy M. ; Orringer, Jeffrey S. ; Hamilton, Ted ; Hammerberg, Craig ; Voorhees, John J. ; Fisher, Gary. / Microdermabrasion : a molecular analysis following a single treatment. In: Journal of the American Academy of Dermatology. 2005 ; Vol. 52, No. 2. pp. 215-223.
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