We have developed a portable, battery operated microcomputer for monitoring vital signs from ambulatory subjects. The targeted application of this device is for monitoring physiological responses from patients with generalized anxiety disorders (GAD). The monitor acquires and analyzes heart rate, respiration rate, skin conductance, temperature, and activity levels from subjects who wear this monitor. A CMOS-based microprocessor system design and low-power analog circuit components allow battery-based operation and data collection for at least 8 hours. During this period vital sign trends are captured through periodic measurements and whenever directed to do so by the patient. This monitor is currently undergoing clinical trials to seek a correlation between subjective reporting of GAD by patients and corresponding physiological responses.