Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation

X. Wang, D. Meier, P. Oya, G. E. Maehlum, D. J. Wagenaar, Benjamin Tsui, B. E. Patt, Eric Frey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The overall aim of this work was to evaluate the potential for improving in vivo small animal microCT through the use of an energy resolved photon-counting detector. To this end, we developed and evaluated a prototype microCT system based on a second-generation photon-counting x-ray detector which simultaneously counted photons with energies above six energy thresholds. First, we developed a threshold tuning procedure to reduce the dependence of detector uniformity and to reduce ring artifacts. Next, we evaluated the system in terms of the contrast-to-noise ratio in different energy windows for different target materials. These differences provided the possibility to weight the data acquired in different windows in order to optimize the contrast-to-noise ratio. We also explored the ability of the system to use data from different energy windows to aid in distinguishing various materials. We found that the energy discrimination capability provided the possibility for improved contrast-to-noise ratios and allowed separation of more than two materials, e.g., bone, soft-tissue and one or more contrast materials having K-absorption edges in the energy ranges of interest.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7622
EditionPART 1
DOIs
StatePublished - 2010
EventMedical Imaging 2010: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 15 2010Feb 18 2010

Other

OtherMedical Imaging 2010: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/15/102/18/10

Fingerprint

x ray detectors
X-Ray Microtomography
Photons
Contrast Media
Tomography
Noise
counting
tomography
X-Rays
Detectors
X rays
photons
Artifacts
energy
Bone
Animals
Tuning
Tissue
Weights and Measures
Bone and Bones

Keywords

  • Contrast analysis
  • Energy resolved photon-counting
  • Material separation
  • Ring reduction

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Wang, X., Meier, D., Oya, P., Maehlum, G. E., Wagenaar, D. J., Tsui, B., ... Frey, E. (2010). Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (PART 1 ed., Vol. 7622). [76221B] https://doi.org/10.1117/12.844301

Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation. / Wang, X.; Meier, D.; Oya, P.; Maehlum, G. E.; Wagenaar, D. J.; Tsui, Benjamin; Patt, B. E.; Frey, Eric.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7622 PART 1. ed. 2010. 76221B.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, X, Meier, D, Oya, P, Maehlum, GE, Wagenaar, DJ, Tsui, B, Patt, BE & Frey, E 2010, Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 1 edn, vol. 7622, 76221B, Medical Imaging 2010: Physics of Medical Imaging, San Diego, CA, United States, 2/15/10. https://doi.org/10.1117/12.844301
Wang X, Meier D, Oya P, Maehlum GE, Wagenaar DJ, Tsui B et al. Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 1 ed. Vol. 7622. 2010. 76221B https://doi.org/10.1117/12.844301
Wang, X. ; Meier, D. ; Oya, P. ; Maehlum, G. E. ; Wagenaar, D. J. ; Tsui, Benjamin ; Patt, B. E. ; Frey, Eric. / Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7622 PART 1. ed. 2010.
@inproceedings{278e0ab9bb9c426da07897bcf1faf6ab,
title = "Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation",
abstract = "The overall aim of this work was to evaluate the potential for improving in vivo small animal microCT through the use of an energy resolved photon-counting detector. To this end, we developed and evaluated a prototype microCT system based on a second-generation photon-counting x-ray detector which simultaneously counted photons with energies above six energy thresholds. First, we developed a threshold tuning procedure to reduce the dependence of detector uniformity and to reduce ring artifacts. Next, we evaluated the system in terms of the contrast-to-noise ratio in different energy windows for different target materials. These differences provided the possibility to weight the data acquired in different windows in order to optimize the contrast-to-noise ratio. We also explored the ability of the system to use data from different energy windows to aid in distinguishing various materials. We found that the energy discrimination capability provided the possibility for improved contrast-to-noise ratios and allowed separation of more than two materials, e.g., bone, soft-tissue and one or more contrast materials having K-absorption edges in the energy ranges of interest.",
keywords = "Contrast analysis, Energy resolved photon-counting, Material separation, Ring reduction",
author = "X. Wang and D. Meier and P. Oya and Maehlum, {G. E.} and Wagenaar, {D. J.} and Benjamin Tsui and Patt, {B. E.} and Eric Frey",
year = "2010",
doi = "10.1117/12.844301",
language = "English (US)",
isbn = "9780819480231",
volume = "7622",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
edition = "PART 1",

}

TY - GEN

T1 - Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation

AU - Wang, X.

AU - Meier, D.

AU - Oya, P.

AU - Maehlum, G. E.

AU - Wagenaar, D. J.

AU - Tsui, Benjamin

AU - Patt, B. E.

AU - Frey, Eric

PY - 2010

Y1 - 2010

N2 - The overall aim of this work was to evaluate the potential for improving in vivo small animal microCT through the use of an energy resolved photon-counting detector. To this end, we developed and evaluated a prototype microCT system based on a second-generation photon-counting x-ray detector which simultaneously counted photons with energies above six energy thresholds. First, we developed a threshold tuning procedure to reduce the dependence of detector uniformity and to reduce ring artifacts. Next, we evaluated the system in terms of the contrast-to-noise ratio in different energy windows for different target materials. These differences provided the possibility to weight the data acquired in different windows in order to optimize the contrast-to-noise ratio. We also explored the ability of the system to use data from different energy windows to aid in distinguishing various materials. We found that the energy discrimination capability provided the possibility for improved contrast-to-noise ratios and allowed separation of more than two materials, e.g., bone, soft-tissue and one or more contrast materials having K-absorption edges in the energy ranges of interest.

AB - The overall aim of this work was to evaluate the potential for improving in vivo small animal microCT through the use of an energy resolved photon-counting detector. To this end, we developed and evaluated a prototype microCT system based on a second-generation photon-counting x-ray detector which simultaneously counted photons with energies above six energy thresholds. First, we developed a threshold tuning procedure to reduce the dependence of detector uniformity and to reduce ring artifacts. Next, we evaluated the system in terms of the contrast-to-noise ratio in different energy windows for different target materials. These differences provided the possibility to weight the data acquired in different windows in order to optimize the contrast-to-noise ratio. We also explored the ability of the system to use data from different energy windows to aid in distinguishing various materials. We found that the energy discrimination capability provided the possibility for improved contrast-to-noise ratios and allowed separation of more than two materials, e.g., bone, soft-tissue and one or more contrast materials having K-absorption edges in the energy ranges of interest.

KW - Contrast analysis

KW - Energy resolved photon-counting

KW - Material separation

KW - Ring reduction

UR - http://www.scopus.com/inward/record.url?scp=84873929654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873929654&partnerID=8YFLogxK

U2 - 10.1117/12.844301

DO - 10.1117/12.844301

M3 - Conference contribution

SN - 9780819480231

VL - 7622

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -