Microcirculation and hemorheology

Aleksander S. Popel, Paul C. Johnson

Research output: Contribution to journalReview article

Abstract

We review major experimental and theoretical studies on microcirculation and hemorheology, focusing on mechanics of blood flow and the vascular wall. We discuss flow of the blood formed elements [red blood cells (RBCs), white blood cells or leukocytes (WBCs) and platelets] in individual arterioles, capillaries, and venules, and in microvascular networks. We also review mechanical and rheological properties of the formed elements and their interactions with the vascular wall. We discuss short-term and long-term regulation of the microvasculature; the modes of regulation include metabolic, myogenic, and shear-stress-dependent mechanisms as well as vascular adaptation such as angiogenesis and vascular remodeling.

Original languageEnglish (US)
Pages (from-to)43-69
Number of pages27
JournalAnnual Review of Fluid Mechanics
Volume37
DOIs
StatePublished - Mar 11 2005

Keywords

  • Biofluidmechanics
  • Blood flow
  • Cell mechanics
  • Computational model
  • Vascular regulation

ASJC Scopus subject areas

  • Condensed Matter Physics

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