Microcirculation and hemorheology

Aleksander S Popel, Paul C. Johnson

Research output: Contribution to journalArticle

Abstract

We review major experimental and theoretical studies on microcirculation and hemorheology, focusing on mechanics of blood flow and the vascular wall. We discuss flow of the blood formed elements [red blood cells (RBCs), white blood cells or leukocytes (WBCs) and platelets] in individual arterioles, capillaries, and venules, and in microvascular networks. We also review mechanical and rheological properties of the formed elements and their interactions with the vascular wall. We discuss short-term and long-term regulation of the microvasculature; the modes of regulation include metabolic, myogenic, and shear-stress-dependent mechanisms as well as vascular adaptation such as angiogenesis and vascular remodeling.

Original languageEnglish (US)
Pages (from-to)43-69
Number of pages27
JournalAnnual Review of Fluid Mechanics
Volume37
DOIs
StatePublished - 2005

Fingerprint

Microcirculation
leukocytes
Blood
arterioles
angiogenesis
erythrocytes
blood flow
platelets
shear stress
blood
Cells
mechanical properties
Platelets
Shear stress
Mechanics
interactions

Keywords

  • Biofluidmechanics
  • Blood flow
  • Cell mechanics
  • Computational model
  • Vascular regulation

ASJC Scopus subject areas

  • Computational Mechanics
  • Condensed Matter Physics

Cite this

Microcirculation and hemorheology. / Popel, Aleksander S; Johnson, Paul C.

In: Annual Review of Fluid Mechanics, Vol. 37, 2005, p. 43-69.

Research output: Contribution to journalArticle

Popel, Aleksander S ; Johnson, Paul C. / Microcirculation and hemorheology. In: Annual Review of Fluid Mechanics. 2005 ; Vol. 37. pp. 43-69.
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