Microchimerism in the transfused obstetric population

E. M. Bloch, M. P. Busch, T. H. Lee, L. Montalvo, Y. Matthews, A. Bird, R. Bruhn, V. Stefan

Research output: Contribution to journalArticlepeer-review

Abstract

Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.

Original languageEnglish (US)
Pages (from-to)428-430
Number of pages3
JournalVox sanguinis
Volume107
Issue number4
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Keywords

  • Blood transfusion
  • Chimerism
  • Peripartum

ASJC Scopus subject areas

  • Hematology

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