Microchimerism in the transfused obstetric population

E. M. Bloch; M. P. Busch; T. H. Lee; L. Montalvo; Y. Matthews; A. Bird; R. Bruhn; V. Stefan

doi:10.1111/vox.12177

Microchimerism in the transfused obstetric population

E. M. Bloch, M. P. Busch, T. H. Lee, L. Montalvo, Y. Matthews, A. Bird, R. Bruhn, V. Stefan

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.

Original language	English (US)
Pages (from-to)	428-430
Number of pages	3
Journal	Vox sanguinis
Volume	107
Issue number	4
DOIs	https://doi.org/10.1111/vox.12177
State	Published - Nov 1 2014
Externally published	Yes

Keywords

Blood transfusion
Chimerism
Peripartum

ASJC Scopus subject areas

Hematology

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10.1111/vox.12177

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title = "Microchimerism in the transfused obstetric population",

abstract = "Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.",

keywords = "Blood transfusion, Chimerism, Peripartum",

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AU - Bloch, E. M.

AU - Busch, M. P.

AU - Lee, T. H.

AU - Montalvo, L.

AU - Matthews, Y.

AU - Bird, A.

AU - Bruhn, R.

AU - Stefan, V.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.

AB - Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.

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KW - Chimerism

KW - Peripartum

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Microchimerism in the transfused obstetric population

Abstract

Keywords

ASJC Scopus subject areas

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