Microbial translocation of the blood-brain barrier

Research output: Contribution to journalArticle

Abstract

A major contributing factor to high mortality and morbidity associated with CNS infection is the incomplete understanding of the pathogenesis of this disease. Relatively small numbers of pathogens account for most cases of CNS infections in humans, but it is unclear how such pathogens cross the blood-brain barrier (BBB) and cause infections. The development of the in vitro BBB model using human brain microvascular endothelial cells has facilitated our understanding of the microbial translocation of the BBB, a key step for the acquisition of CNS infections. Recent studies have revealed that microbial translocation of the BBB involves host cell actin cytoskeletal rearrangements, most likely as the result of specific microbial-host interactions. A better understanding of microbial-host interactions that are involved in microbial translocation of the BBB should help in developing new strategies to prevent CNS infections. This review summarises our current understanding of the pathogenic mechanisms involved in translocation of the BBB by meningitis-causing bacteria, fungi and parasites.

Original languageEnglish (US)
Pages (from-to)607-614
Number of pages8
JournalInternational Journal for Parasitology
Volume36
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Blood-Brain Barrier
Microbial Interactions
Infection
Meningitis
Actins
Parasites
Fungi
Endothelial Cells
Morbidity
Bacteria
Mortality
Brain

Keywords

  • Actin cytoskeleton rearrangement
  • Blood-brain barrier
  • Central nervous system infection
  • Human brain microvascular endothelial cells
  • Pathogenesis
  • Signal transduction

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Microbial translocation of the blood-brain barrier. / Kim, Kwang Sik.

In: International Journal for Parasitology, Vol. 36, No. 5, 05.2006, p. 607-614.

Research output: Contribution to journalArticle

@article{5feb86030560445aa00a9a88f90013f9,
title = "Microbial translocation of the blood-brain barrier",
abstract = "A major contributing factor to high mortality and morbidity associated with CNS infection is the incomplete understanding of the pathogenesis of this disease. Relatively small numbers of pathogens account for most cases of CNS infections in humans, but it is unclear how such pathogens cross the blood-brain barrier (BBB) and cause infections. The development of the in vitro BBB model using human brain microvascular endothelial cells has facilitated our understanding of the microbial translocation of the BBB, a key step for the acquisition of CNS infections. Recent studies have revealed that microbial translocation of the BBB involves host cell actin cytoskeletal rearrangements, most likely as the result of specific microbial-host interactions. A better understanding of microbial-host interactions that are involved in microbial translocation of the BBB should help in developing new strategies to prevent CNS infections. This review summarises our current understanding of the pathogenic mechanisms involved in translocation of the BBB by meningitis-causing bacteria, fungi and parasites.",
keywords = "Actin cytoskeleton rearrangement, Blood-brain barrier, Central nervous system infection, Human brain microvascular endothelial cells, Pathogenesis, Signal transduction",
author = "Kim, {Kwang Sik}",
year = "2006",
month = "5",
doi = "10.1002/uog.3757",
language = "English (US)",
volume = "36",
pages = "607--614",
journal = "International Journal for Parasitology",
issn = "0020-7519",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Microbial translocation of the blood-brain barrier

AU - Kim, Kwang Sik

PY - 2006/5

Y1 - 2006/5

N2 - A major contributing factor to high mortality and morbidity associated with CNS infection is the incomplete understanding of the pathogenesis of this disease. Relatively small numbers of pathogens account for most cases of CNS infections in humans, but it is unclear how such pathogens cross the blood-brain barrier (BBB) and cause infections. The development of the in vitro BBB model using human brain microvascular endothelial cells has facilitated our understanding of the microbial translocation of the BBB, a key step for the acquisition of CNS infections. Recent studies have revealed that microbial translocation of the BBB involves host cell actin cytoskeletal rearrangements, most likely as the result of specific microbial-host interactions. A better understanding of microbial-host interactions that are involved in microbial translocation of the BBB should help in developing new strategies to prevent CNS infections. This review summarises our current understanding of the pathogenic mechanisms involved in translocation of the BBB by meningitis-causing bacteria, fungi and parasites.

AB - A major contributing factor to high mortality and morbidity associated with CNS infection is the incomplete understanding of the pathogenesis of this disease. Relatively small numbers of pathogens account for most cases of CNS infections in humans, but it is unclear how such pathogens cross the blood-brain barrier (BBB) and cause infections. The development of the in vitro BBB model using human brain microvascular endothelial cells has facilitated our understanding of the microbial translocation of the BBB, a key step for the acquisition of CNS infections. Recent studies have revealed that microbial translocation of the BBB involves host cell actin cytoskeletal rearrangements, most likely as the result of specific microbial-host interactions. A better understanding of microbial-host interactions that are involved in microbial translocation of the BBB should help in developing new strategies to prevent CNS infections. This review summarises our current understanding of the pathogenic mechanisms involved in translocation of the BBB by meningitis-causing bacteria, fungi and parasites.

KW - Actin cytoskeleton rearrangement

KW - Blood-brain barrier

KW - Central nervous system infection

KW - Human brain microvascular endothelial cells

KW - Pathogenesis

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=33646375687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646375687&partnerID=8YFLogxK

U2 - 10.1002/uog.3757

DO - 10.1002/uog.3757

M3 - Article

C2 - 16542662

AN - SCOPUS:33646375687

VL - 36

SP - 607

EP - 614

JO - International Journal for Parasitology

JF - International Journal for Parasitology

SN - 0020-7519

IS - 5

ER -