TY - JOUR
T1 - Microbial synergy in experimental intra abdominal abscess
AU - Onderdonk, Andrew B.
AU - Bartlett, John G.
AU - Louie, Thomas
AU - Sullivan-Seigler, Nadine
AU - Gorbach, Sherwood L.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1976
Y1 - 1976
N2 - Intra abdominal sepsis was studied in Wistar rats by using four microbial species: Escherichia coli, enterococci, Bacteroides fragilis, and Fusobacterium varium. These organisms were implanted into the peritoneal cavity singly and in all possible dual combinations. Results were evaluated by mortality rates and the incidence of intra abdominal abscesses on autopsy following sacrifice after 7 days. Mortality was restricted to recipients of E. coli, thus implicating coliforms in the acute lethality associated with this experimental model. Intra abdominal abscesses were produced in 61 of 65 (94%) animals that received the combination of an anaerobe and a facultative organism. Abscesses failed to form with any single strain or with E. coli plus enterococci, and they were detected in one 1 of 19 animals receiving B. fragilis plus F. varium. These results suggest that intra abdominal abscess formation is related to synergy between anaerobes and facultative bacteria.
AB - Intra abdominal sepsis was studied in Wistar rats by using four microbial species: Escherichia coli, enterococci, Bacteroides fragilis, and Fusobacterium varium. These organisms were implanted into the peritoneal cavity singly and in all possible dual combinations. Results were evaluated by mortality rates and the incidence of intra abdominal abscesses on autopsy following sacrifice after 7 days. Mortality was restricted to recipients of E. coli, thus implicating coliforms in the acute lethality associated with this experimental model. Intra abdominal abscesses were produced in 61 of 65 (94%) animals that received the combination of an anaerobe and a facultative organism. Abscesses failed to form with any single strain or with E. coli plus enterococci, and they were detected in one 1 of 19 animals receiving B. fragilis plus F. varium. These results suggest that intra abdominal abscess formation is related to synergy between anaerobes and facultative bacteria.
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U2 - 10.1128/iai.13.1.22-26.1976
DO - 10.1128/iai.13.1.22-26.1976
M3 - Article
C2 - 814099
AN - SCOPUS:0017295713
SN - 0309-1708
VL - 13
SP - 22
EP - 26
JO - Unknown Journal
JF - Unknown Journal
IS - 1
ER -