Microbial synergy in experimental intra abdominal abscess

A. B. Onderdonk, John Bartlett, T. Louie, N. Sullivan-Seigler, S. L. Gorbach

Research output: Contribution to journalArticle

Abstract

Intra abdominal sepsis was studied in Wistar rats by using four microbial species: Escherichia coli, enterococci, Bacteroides fragilis, and Fusobacterium varium. These organisms were implanted into the peritoneal cavity singly and in all possible dual combinations. Results were evaluated by mortality rates and the incidence of intra abdominal abscesses on autopsy following sacrifice after 7 days. Mortality was restricted to recipients of E. coli, thus implicating coliforms in the acute lethality associated with this experimental model. Intra abdominal abscesses were produced in 61 of 65 (94%) animals that received the combination of an anaerobe and a facultative organism. Abscesses failed to form with any single strain or with E. coli plus enterococci, and they were detected in one 1 of 19 animals receiving B. fragilis plus F. varium. These results suggest that intra abdominal abscess formation is related to synergy between anaerobes and facultative bacteria.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalInfection and Immunity
Volume13
Issue number1
StatePublished - 1976
Externally publishedYes

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Abdominal Abscess
Bacteroides fragilis
Enterococcus
Escherichia coli
Fusobacterium
Mortality
Peritoneal Cavity
Abscess
Wistar Rats
Autopsy
Sepsis
Theoretical Models
Bacteria
Incidence

ASJC Scopus subject areas

  • Immunology

Cite this

Onderdonk, A. B., Bartlett, J., Louie, T., Sullivan-Seigler, N., & Gorbach, S. L. (1976). Microbial synergy in experimental intra abdominal abscess. Infection and Immunity, 13(1), 22-26.

Microbial synergy in experimental intra abdominal abscess. / Onderdonk, A. B.; Bartlett, John; Louie, T.; Sullivan-Seigler, N.; Gorbach, S. L.

In: Infection and Immunity, Vol. 13, No. 1, 1976, p. 22-26.

Research output: Contribution to journalArticle

Onderdonk, AB, Bartlett, J, Louie, T, Sullivan-Seigler, N & Gorbach, SL 1976, 'Microbial synergy in experimental intra abdominal abscess', Infection and Immunity, vol. 13, no. 1, pp. 22-26.
Onderdonk AB, Bartlett J, Louie T, Sullivan-Seigler N, Gorbach SL. Microbial synergy in experimental intra abdominal abscess. Infection and Immunity. 1976;13(1):22-26.
Onderdonk, A. B. ; Bartlett, John ; Louie, T. ; Sullivan-Seigler, N. ; Gorbach, S. L. / Microbial synergy in experimental intra abdominal abscess. In: Infection and Immunity. 1976 ; Vol. 13, No. 1. pp. 22-26.
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